Control of neuronal excitability by corticosteroid hormones

M JOELS; ER DEKLOET

doi:10.1016/0166-2236(92)90345-9

Control of neuronal excitability by corticosteroid hormones

M JOELS^*, ER DEKLOET

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Article › Academic › peer-review

362 Citations (Scopus)

Abstract

The rat adrenal hormone corticosterone can cross the blood-brain barrier and bind to two intracellular receptor populations in the brain - the mineralocorticoid and glucocorticoid receptor. Recent studies have revealed that the corticosteroid hormones are able to restore changes in neuronal membrane properties induced by current or neurotransmitters, probably through a genomic action. In general, mineralocorticoid receptors mediate steroid actions that enhance cellular excitability, whereas activated glucocorticoid receptors can suppress temporarily raised neuronal activity. The steroid-mediated control of excitability and the implications for information processing in the brain are reviewed in this article.

Original language	English
Pages (from-to)	25-30
Number of pages	6
Journal	Trends in neurosciences
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/0166-2236(92)90345-9
Publication status	Published - Jan-1992

Keywords

HIPPOCAMPAL SLICE ELECTROPHYSIOLOGY
ADRENALECTOMIZED BALB/C MICE
RECEPTOR MESSENGER-RNAS
PYRAMIDAL CELLS-INVITRO
LONG-TERM POTENTIATION
GLUCOCORTICOID RECEPTOR
MINERALOCORTICOID RECEPTOR
RAT HIPPOCAMPUS
NERVOUS-SYSTEM
LOCALIZATION

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Control of neuronal excitability by corticosteroid hormones
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title = "Control of neuronal excitability by corticosteroid hormones",

abstract = "The rat adrenal hormone corticosterone can cross the blood-brain barrier and bind to two intracellular receptor populations in the brain - the mineralocorticoid and glucocorticoid receptor. Recent studies have revealed that the corticosteroid hormones are able to restore changes in neuronal membrane properties induced by current or neurotransmitters, probably through a genomic action. In general, mineralocorticoid receptors mediate steroid actions that enhance cellular excitability, whereas activated glucocorticoid receptors can suppress temporarily raised neuronal activity. The steroid-mediated control of excitability and the implications for information processing in the brain are reviewed in this article.",

keywords = "HIPPOCAMPAL SLICE ELECTROPHYSIOLOGY, ADRENALECTOMIZED BALB/C MICE, RECEPTOR MESSENGER-RNAS, PYRAMIDAL CELLS-INVITRO, LONG-TERM POTENTIATION, GLUCOCORTICOID RECEPTOR, MINERALOCORTICOID RECEPTOR, RAT HIPPOCAMPUS, NERVOUS-SYSTEM, LOCALIZATION",

author = "M JOELS and ER DEKLOET",

year = "1992",

month = jan,

doi = "10.1016/0166-2236(92)90345-9",

language = "English",

volume = "15",

pages = "25--30",

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T1 - Control of neuronal excitability by corticosteroid hormones

AU - JOELS, M

AU - DEKLOET, ER

PY - 1992/1

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N2 - The rat adrenal hormone corticosterone can cross the blood-brain barrier and bind to two intracellular receptor populations in the brain - the mineralocorticoid and glucocorticoid receptor. Recent studies have revealed that the corticosteroid hormones are able to restore changes in neuronal membrane properties induced by current or neurotransmitters, probably through a genomic action. In general, mineralocorticoid receptors mediate steroid actions that enhance cellular excitability, whereas activated glucocorticoid receptors can suppress temporarily raised neuronal activity. The steroid-mediated control of excitability and the implications for information processing in the brain are reviewed in this article.

AB - The rat adrenal hormone corticosterone can cross the blood-brain barrier and bind to two intracellular receptor populations in the brain - the mineralocorticoid and glucocorticoid receptor. Recent studies have revealed that the corticosteroid hormones are able to restore changes in neuronal membrane properties induced by current or neurotransmitters, probably through a genomic action. In general, mineralocorticoid receptors mediate steroid actions that enhance cellular excitability, whereas activated glucocorticoid receptors can suppress temporarily raised neuronal activity. The steroid-mediated control of excitability and the implications for information processing in the brain are reviewed in this article.

KW - HIPPOCAMPAL SLICE ELECTROPHYSIOLOGY

KW - ADRENALECTOMIZED BALB/C MICE

KW - RECEPTOR MESSENGER-RNAS

KW - PYRAMIDAL CELLS-INVITRO

KW - LONG-TERM POTENTIATION

KW - GLUCOCORTICOID RECEPTOR

KW - MINERALOCORTICOID RECEPTOR

KW - RAT HIPPOCAMPUS

KW - NERVOUS-SYSTEM

KW - LOCALIZATION

U2 - 10.1016/0166-2236(92)90345-9

DO - 10.1016/0166-2236(92)90345-9

M3 - Article

VL - 15

SP - 25

EP - 30

JO - Trends in neurosciences

JF - Trends in neurosciences

SN - 0166-2236

IS - 1

ER -