Abstract
The rat adrenal hormone corticosterone can cross the blood-brain barrier and bind to two intracellular receptor populations in the brain - the mineralocorticoid and glucocorticoid receptor. Recent studies have revealed that the corticosteroid hormones are able to restore changes in neuronal membrane properties induced by current or neurotransmitters, probably through a genomic action. In general, mineralocorticoid receptors mediate steroid actions that enhance cellular excitability, whereas activated glucocorticoid receptors can suppress temporarily raised neuronal activity. The steroid-mediated control of excitability and the implications for information processing in the brain are reviewed in this article.
Original language | English |
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Pages (from-to) | 25-30 |
Number of pages | 6 |
Journal | Trends in neurosciences |
Volume | 15 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan-1992 |
Keywords
- HIPPOCAMPAL SLICE ELECTROPHYSIOLOGY
- ADRENALECTOMIZED BALB/C MICE
- RECEPTOR MESSENGER-RNAS
- PYRAMIDAL CELLS-INVITRO
- LONG-TERM POTENTIATION
- GLUCOCORTICOID RECEPTOR
- MINERALOCORTICOID RECEPTOR
- RAT HIPPOCAMPUS
- NERVOUS-SYSTEM
- LOCALIZATION