Control of neuronal excitability by corticosteroid hormones

M JOELS*, ER DEKLOET

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

354 Citations (Scopus)

Abstract

The rat adrenal hormone corticosterone can cross the blood-brain barrier and bind to two intracellular receptor populations in the brain - the mineralocorticoid and glucocorticoid receptor. Recent studies have revealed that the corticosteroid hormones are able to restore changes in neuronal membrane properties induced by current or neurotransmitters, probably through a genomic action. In general, mineralocorticoid receptors mediate steroid actions that enhance cellular excitability, whereas activated glucocorticoid receptors can suppress temporarily raised neuronal activity. The steroid-mediated control of excitability and the implications for information processing in the brain are reviewed in this article.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalTrends in neurosciences
Volume15
Issue number1
DOIs
Publication statusPublished - Jan-1992

Keywords

  • HIPPOCAMPAL SLICE ELECTROPHYSIOLOGY
  • ADRENALECTOMIZED BALB/C MICE
  • RECEPTOR MESSENGER-RNAS
  • PYRAMIDAL CELLS-INVITRO
  • LONG-TERM POTENTIATION
  • GLUCOCORTICOID RECEPTOR
  • MINERALOCORTICOID RECEPTOR
  • RAT HIPPOCAMPUS
  • NERVOUS-SYSTEM
  • LOCALIZATION

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