Controling stem cell proliferation - CKIs at work

SWM Bruggeman, M van Lohuizen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

Original languageEnglish
Pages (from-to)1281-1285
Number of pages5
JournalCell Cycle
Volume5
Issue number12
Publication statusPublished - 15-Jun-2006

Keywords

  • CKI
  • adult stem cells
  • self-renewal
  • polycomb group
  • Bmi1
  • SELF-RENEWAL
  • TUMOR SUPPRESSION
  • CDK INHIBITORS
  • MICE LACKING
  • ES CELLS
  • ASYMMETRIC SEGREGATION
  • PROGENITOR CELLS
  • CYCLE ARREST
  • SENESCENCE
  • MOUSE

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