Abstract
The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.
| Original language | English |
|---|---|
| Pages (from-to) | 1281-1285 |
| Number of pages | 5 |
| Journal | Cell Cycle |
| Volume | 5 |
| Issue number | 12 |
| Publication status | Published - 15-Jun-2006 |
Keywords
- CKI
- adult stem cells
- self-renewal
- polycomb group
- Bmi1
- SELF-RENEWAL
- TUMOR SUPPRESSION
- CDK INHIBITORS
- MICE LACKING
- ES CELLS
- ASYMMETRIC SEGREGATION
- PROGENITOR CELLS
- CYCLE ARREST
- SENESCENCE
- MOUSE