Controling stem cell proliferation - CKIs at work

SWM Bruggeman; M van Lohuizen

Controling stem cell proliferation - CKIs at work

SWM Bruggeman
, M van Lohuizen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

Original language	English
Pages (from-to)	1281-1285
Number of pages	5
Journal	Cell Cycle
Volume	5
Issue number	12
Publication status	Published - 15-Jun-2006

Keywords

CKI
adult stem cells
self-renewal
polycomb group
Bmi1
SELF-RENEWAL
TUMOR SUPPRESSION
CDK INHIBITORS
MICE LACKING
ES CELLS
ASYMMETRIC SEGREGATION
PROGENITOR CELLS
CYCLE ARREST
SENESCENCE
MOUSE

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@article{505ed67eaa814bd6a54486324570878c,

title = "Controling stem cell proliferation - CKIs at work",

abstract = "The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.",

keywords = "CKI, adult stem cells, self-renewal, polycomb group, Bmi1, SELF-RENEWAL, TUMOR SUPPRESSION, CDK INHIBITORS, MICE LACKING, ES CELLS, ASYMMETRIC SEGREGATION, PROGENITOR CELLS, CYCLE ARREST, SENESCENCE, MOUSE",

author = "SWM Bruggeman and \{van Lohuizen\}, M",

year = "2006",

month = jun,

day = "15",

language = "English",

volume = "5",

pages = "1281--1285",

journal = "Cell Cycle",

issn = "1538-4101",

publisher = "Taylor \& Francis Group",

number = "12",

}

TY - JOUR

T1 - Controling stem cell proliferation - CKIs at work

AU - Bruggeman, SWM

AU - van Lohuizen, M

PY - 2006/6/15

Y1 - 2006/6/15

N2 - The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

AB - The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

KW - CKI

KW - adult stem cells

KW - self-renewal

KW - polycomb group

KW - Bmi1

KW - SELF-RENEWAL

KW - TUMOR SUPPRESSION

KW - CDK INHIBITORS

KW - MICE LACKING

KW - ES CELLS

KW - ASYMMETRIC SEGREGATION

KW - PROGENITOR CELLS

KW - CYCLE ARREST

KW - SENESCENCE

KW - MOUSE

M3 - Article

SN - 1538-4101

VL - 5

SP - 1281

EP - 1285

JO - Cell Cycle

JF - Cell Cycle

IS - 12

ER -

Controling stem cell proliferation - CKIs at work

Abstract

Keywords

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