Controlling miRNA regulation in disease

Willemijn M. Gommans, Eugene Berezikov*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

29 Citations (Scopus)

Abstract

Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfill important functions in cellular behavior by influencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression. On the other side, mRNA molecules might be able to escape the regulation by miRNAs. In this review, we give an overview on how miRNA biogenesis can be altered in disease as well as how mRNAs can avoid the regulation by miRNAs. The interplay between these two processes defines the final protein output in a cell, and thus the normal or pathological cellular phenotype.

Original languageEnglish
Title of host publicationNext-Generation MicroRNA Expression Profiling Technology
Subtitle of host publicationMethods and Protocols
EditorsJian-Bing Fan
Pages1-18
Number of pages18
DOIs
Publication statusPublished - 23-Jan-2012

Publication series

NameMethods in Molecular Biology
Volume822
ISSN (Print)1064-3745

Keywords

  • microRNA
  • microRNA biogenesis
  • microRNA expression in disease
  • microRNA expression regulation
  • microRNA regulation in disease

Cite this