Copper-catalysed alkylation of heterocyclic acceptors with organometallic reagents

Yafei Guo, Syuzanna R. Harutyunyan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
61 Downloads (Pure)

Abstract

Copper-catalysed asymmetric C-C bond-forming reactions using organometallic reagents have developed into a powerful tool for the synthesis of complex molecules with single or multiple stereogenic centres over the past decades. Among the various acceptors employed in such reactions, those with a heterocyclic core are of particular importance because of the frequent occurrence of heterocyclic scaffolds in the structures of chiral natural products and bioactive molecules. Hence, this review focuses on the progress made over the past 20 years for heterocyclic acceptors.

Original languageEnglish
Pages (from-to)1006-1021
Number of pages16
JournalBeilstein Journal of Organic Chemistry
Volume16
DOIs
Publication statusPublished - 14-May-2020

Keywords

  • conjugate addition
  • copper catalysis
  • heterocyclic Michael acceptor
  • organometallics
  • ASYMMETRIC CONJUGATE ADDITION
  • ENANTIOSELECTIVE TOTAL-SYNTHESIS
  • DIALKYLZINC REAGENTS
  • ALLYLIC ALKYLATION
  • GRIGNARD-REAGENTS
  • ALKENYL
  • 1,4-ADDITION
  • LIGANDS

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