Copper-Catalyzed Enantioselective Alkylation of Enolizable Ketimines with Organomagnesium Reagents

Pablo Ortiz, Juan Collados Lujan, Ravindra P Jumde, Edwin Otten, Syuzanna R Harutyunyan

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Abstract

Inexpensive and readily available organomagnesium reagents were used for the catalytic enantioselective alkylation of enolizable N-sulfonyl ketimines. The low reactivity and competing enolization of the ketimines was overcome by the use of a copper-phosphine chiral catalyst, which also rendered the transformation highly chemoselective and enantioselective for a broad range of ketimine substrates.

Original languageEnglish
Pages (from-to)3041-3044
Number of pages4
JournalAngewandte Chemie - International Edition
Volume56
Issue number11
DOIs
Publication statusPublished - 2017

Keywords

  • Journal Article

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