Copper-Catalyzed Modular Assembly of Polyheterocycles

Qian Wang, Jesse Tuinhof, Kumchok C Mgimpatsang, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.

Original languageEnglish
Pages (from-to)9915-9927
Number of pages13
JournalThe Journal of Organic Chemistry
Issue number15
Publication statusE-pub ahead of print - 12-Jul-2020

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