Copper-Catalyzed Modular Assembly of Polyheterocycles

Qian Wang; Jesse Tuinhof; Kumchok C Mgimpatsang; Katarzyna Kurpiewska; Justyna Kalinowska-Tluscik; Alexander Dömling

doi:10.1021/acs.joc.0c01238

Copper-Catalyzed Modular Assembly of Polyheterocycles

Qian Wang, Jesse Tuinhof, Kumchok C Mgimpatsang, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Dömling^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.

Original language	English
Pages (from-to)	9915-9927
Number of pages	13
Journal	The Journal of Organic Chemistry
Volume	85
Issue number	15
DOIs	https://doi.org/10.1021/acs.joc.0c01238
Publication status	E-pub ahead of print - 12-Jul-2020

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Copper-Catalyzed Modular Assembly of PolyheterocyclesProof, 1.47 MBLicence: CC BY-NC-ND

Cite this

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AU - Mgimpatsang, Kumchok C

AU - Kurpiewska, Katarzyna

AU - Kalinowska-Tluscik, Justyna

AU - Dömling, Alexander

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AB - Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.

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DO - 10.1021/acs.joc.0c01238

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