Correlates and outcomes of alcohol use after single solid organ transplantation: A systematic review and meta-analysis

B-SERIOUS Consortium

    Research output: Contribution to journalReview articlepeer-review

    3 Citations (Scopus)

    Abstract

    Background: Reviews on alcohol use in transplant recipients focus on liver recipients and their risk of post-transplant rejection, but do not assess alcohol use in kidney, heart, or lung transplant recipients. This systematic review and meta-analysis aims to synthesize the evidence on correlates and outcomes of any alcohol use and at-risk drinking after solid organ transplantation (Tx).

    Methods: We searched 4 databases for quantitative studies in adult heart, liver, kidney and lung Tx recipients, investigating associations between post-Tx alcohol use and correlates and/or clinical, economic or quality of life outcomes. Paper selection, data extraction and quality assessment were performed by 2 reviewers independently. A pooled odds ratio (OR) was computed for each correlate/outcome reported >= 5 times.

    Results: Of the 5331 studies identified, 76 were included in this systematic review (93.3% on liver Tx; mean sample size 148.9 (SD = 160.2); 71.9% male; mean age 48.9 years (SD = 6.5); mean time post-Tx 57.7 months (SD = 23.1)). On average, 23.6% of patients studied used alcohol post-transplant. Ninety-three correlates of any post-Tx alcohol use were identified, and 9 of the 19 pooled ORs were significantly associated with a higher odds for any post-Tx alcohol use: male gender, being employed post-transplant, smoking pre-transplant, smoking post transplant, a history of illicit drug use, having first-degree relatives who have alcohol-related problems, sobriety

    Conclusion: Correlates of alcohol use remain under-investigated in solid organ transplant recipients other than liver transplantation. Further research is needed to determine whether any alcohol use or at-risk drinking is associated with poorer post-transplant outcomes. Our meta-analysis highlights avenues for future research of higher methodological quality and improved clinical care. (C) 2018 Elsevier Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)17-28
    Number of pages12
    JournalTransplantation Reviews
    Volume33
    Issue number1
    DOIs
    Publication statusPublished - Jan-2019

    Keywords

    • Alcohol use
    • Solid organ transplantation
    • Systematic review
    • Meta-analysis
    • Risk factors
    • Post-transplant outcome
    • ORTHOTOPIC LIVER-TRANSPLANTATION
    • TERM-FOLLOW-UP
    • CARBOHYDRATE-DEFICIENT TRANSFERRIN
    • RISK-FACTORS
    • RETROSPECTIVE ANALYSIS
    • ABSTINENCE RULE
    • SUBSTANCE-ABUSE
    • RELAPSE SCALE
    • GLOBAL BURDEN
    • TOBACCO USE

    Cite this