Correlation between serum ferritin levels and liver iron concentration determined by MR imaging: impact of hematologic disease and inflammation

Allard W. Olthof*, Paul E. Sijens, Herman G. Kreeftenberg, Peter Kappert, Roy Irwan, Eric J. van der Jagt, Matthijs Oudkerk

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    27 Citations (Scopus)

    Abstract

    Liver iron concentration was determined in 28 patients by magnetic resonance imaging using the method of Gandon et al. (Non-invasive assessment of hepatic iron stores by MRI. Lancet 2004;363:357-362). The result showed a significant correlation with blood plasma ferritin content (Spearman's r = .66; P <.001) and a slightly improving correlation coefficient when limited to those patients not known to have inflammation (r = .82; n = 17; P <.001). Zooming in on patients with hematologic disease also had a beneficial effect on the correlation between liver iron content and plasma ferritin level (r = .79; n = 13; P = .001). It is concluded that in patients without inflammation and in patients with hematologic disease, the content of ferritin in blood is a better predictor of liver iron content than in other patient categories. (c) 2007 Elsevier Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)228-231
    Number of pages4
    JournalMagnetic Resonance Imaging
    Volume25
    Issue number2
    DOIs
    Publication statusPublished - Feb-2007

    Keywords

    • magnetic resonance imaging
    • liver
    • iron
    • ferritin
    • BETA-THALASSEMIA
    • STORES
    • DISORDERS

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