Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (vol 48, pg 624, 2016)

Aysu Okbay, Bart M. L. Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G. Nivard, Mark Alan Fontana, S. Fleur W. Meddens, Richard Karlsson Linner, Cornelius A. Rietveld, Jaime Derringer, Jacob Gratten, James J. Lee, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria GarfieldMarie Henrike Geisel, Juan R. Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J. van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Harm-Jan Westra, Meena Kumari, Lude Franke, Harold Snieder, Ute Bultmann, Melinda Mills, Albertine J. Oldehinkel, Behrooz Z. Alizadeh, Lifelines Cohort Study

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Original languageEnglish
Pages (from-to)1587-1587
Number of pages1
JournalNature Genetics
Volume48
Issue number8
DOIs
Publication statusPublished - Aug-2016

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