Corrigendum to “Genetics of upper limb tremor in clinical practice: a systematic literature review” [Parkinsonism and Related disorders volume “in press” (2025) PRD 107981] (Parkinsonism and Related Disorders (2025) 139, (S1353802025007229), (10.1016/j.parkreldis.2025.107981))

 Introduction: According to the Tremor Study Group's consensus statement of the International Parkinson and Movement Disorder Society (MDS), genetics are crucial in determining tremor etiology. However, the pace of genetic discovery in movement disorders has made it difficult to stay up to date. While MDS gene lists exist for other movement disorders, none yet exist for tremor—the most common. This systematic review aims to identify disease genes causing upper limb tremor and create a list with (likely) pathogenic variants to support genetic testing. 

Methods: Using PRISMA methodology, we systematically reviewed the literature up to 1-1-2025. Tremor did not need to be the main movement disorder. Genes are reported when a (likely) pathogenic variant is reported in multiple unrelated individuals or in at least two independent families. 

Results: We identified 110 disease genes associated with tremor across 300 studies. Genes were categorized by prominent additional signs: ataxia (e.g. SCA-ATXN2, FMR1), parkinsonism (e.g. PARK-LRRK2, PARK-parkin), dystonia (e.g. DYT-ATP7B, ANO3), neurodevelopmental symptoms (e.g. DHDDS, MECP2), neuropathy (e.g. PMP22, AR), and myoclonus (e.g. SAMD12, STARD7). 

Conclusion: This review provides a comprehensive list of genes in which pathogenic variants may lead to upper limb tremor with additional signs. Although no genes were found to cause isolated tremor, tremor can be the first symptom. Clinicians should note that exome sequencing does not detect all relevant variant types, and that acquired causes must also be excluded. This gene list offers a practical tool to connect detailed clinical phenotyping to appropriate genetic testing in complex tremor syndromes. The authors would like to apologise for any inconvenience caused.