Cortactin expression assessment improves patient selection for a watchful waiting strategy in pT1cN0-staged oral squamous cell carcinomas with a tumor infiltration depth below 4 mm

Koos Boeve, Mirjam F Mastik, Lorian Slagter-Menkema, Boukje A C van Dijk, Jan L N Roodenburg, Bernard F A M van der Laan, Max J H Witjes, Bert van der Vegt, Ed Schuuring*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background In this feasibility study we aimed to evaluate the value of previously reported molecular tumor biomarkers associated with lymph node metastasis in oral squamous cell carcinoma (OSCC) to optimize neck strategy selection criteria.

Methods The association between expression of cortactin, cyclin D1, FADD, RAB25, and S100A9 and sentinel lymph node status was evaluated in a series of 87 (cT1-2N0) patients with OSCC treated with primary resection and SLNB procedure.

Results Tumor infiltration depth and tumor pattern of invasion were independent prognostic markers for SLN status, while none of the tumor makers showed a better prognostic value to replace SLNB as neck staging technique in the total cohort. However, in the subgroup of patients with pT1N0 OSCC, cortactin expression (OR 16.0, 95%CI 2.0-127.9) was associated with SLN classification.

Conclusions Expression of cortactin is a promising immunohistochemical tumor marker to identify patients at low risk that may not benefit from SLNB or END.

Original languageEnglish
Number of pages10
JournalHead and Neck: Journal of the Sciences and Specialties of the Head and Neck
DOIs
Publication statusE-pub ahead of print - 19-May-2021

Keywords

  • lymph node classification
  • molecular marker
  • oral cancer
  • oral squamous cell carcinoma
  • sentinel lymph node biopsy
  • SENTINEL NODE BIOPSY
  • LYMPHATIC DRAINAGE PATTERNS
  • ELECTIVE NECK DISSECTION
  • 11Q13 AMPLIFICATION
  • FADD EXPRESSION
  • CYCLIN D1
  • CANCER
  • OVEREXPRESSION
  • METASTASIS
  • PREDICTOR

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