Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective

Olof Wiegert; Marian Joels; Harm J. Krugers

doi:10.1016/S0079-6123(07)67021-6

Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective

Olof Wiegert^*, Marian Joels, Harm J. Krugers

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

10 Citations (Scopus)

Abstract

Emotionally loaded and stressful events modulate cognitive performance. This modulation of cognitive performance is at least partially dependent on corticosteroid hormones that are released in high amounts during emotional or stressful events. Corticosterone both strengthens and suppresses cognitive performance and synaptic plasticity. These effects may critically depend on the timing of the stressful event and corticosteroid exposure with respect to the learning situation. Based on recent findings we propose a model in which corticosterone can rapidly enhance synaptic plasticity. Later, corticosterone may stabilize synaptic efficacy, possibly at the expense of reduced synaptic plasticity.

Original language	English
Title of host publication	STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES
Editors	ER DeKloet, E Vermetten
Publisher	ELSEVIER SCIENCE BV
Pages	269-271
Number of pages	3
ISBN (Print)	978-0-444-53140-7
DOIs	https://doi.org/10.1016/S0079-6123(07)67021-6
Publication status	Published - 2007
Externally published	Yes
Event	Colloquium on Stress Hormones and Post Traumatic Stress Disorder - Basic Studies and Clinical Perspectives - Amsterdam, Netherlands Duration: 28-Aug-2006 → 30-Aug-2006

Publication series

Name	Progress in Brain Research
Publisher	ELSEVIER SCIENCE BV
Volume	167
ISSN (Print)	0079-6123

Conference

Conference	Colloquium on Stress Hormones and Post Traumatic Stress Disorder - Basic Studies and Clinical Perspectives
Country/Territory	Netherlands
City	Amsterdam
Period	28/08/2006 → 30/08/2006

Keywords

RECEPTOR TRAFFICKING
HIPPOCAMPAL
POTENTIATION
PLASTICITY

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Wiegert, O., Joels, M., & Krugers, H. J. (2007). Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective. In ER. DeKloet, & E. Vermetten (Eds.), STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES (pp. 269-271). (Progress in Brain Research; Vol. 167). ELSEVIER SCIENCE BV. https://doi.org/10.1016/S0079-6123(07)67021-6

Wiegert, Olof ; Joels, Marian ; Krugers, Harm J. / Corticosteroid hormones, synaptic strength and emotional memories : Corticosteroid modulation of memory - a cellular and molecular perspective. STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES. editor / ER DeKloet ; E Vermetten. ELSEVIER SCIENCE BV, 2007. pp. 269-271 (Progress in Brain Research).

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title = "Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective",

abstract = "Emotionally loaded and stressful events modulate cognitive performance. This modulation of cognitive performance is at least partially dependent on corticosteroid hormones that are released in high amounts during emotional or stressful events. Corticosterone both strengthens and suppresses cognitive performance and synaptic plasticity. These effects may critically depend on the timing of the stressful event and corticosteroid exposure with respect to the learning situation. Based on recent findings we propose a model in which corticosterone can rapidly enhance synaptic plasticity. Later, corticosterone may stabilize synaptic efficacy, possibly at the expense of reduced synaptic plasticity.",

keywords = "RECEPTOR TRAFFICKING, HIPPOCAMPAL, POTENTIATION, PLASTICITY",

author = "Olof Wiegert and Marian Joels and Krugers, {Harm J.}",

year = "2007",

doi = "10.1016/S0079-6123(07)67021-6",

language = "English",

isbn = "978-0-444-53140-7",

series = "Progress in Brain Research",

publisher = "ELSEVIER SCIENCE BV",

pages = "269--271",

editor = "ER DeKloet and E Vermetten",

booktitle = "STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES",

note = "Colloquium on Stress Hormones and Post Traumatic Stress Disorder - Basic Studies and Clinical Perspectives ; Conference date: 28-08-2006 Through 30-08-2006",

}

Wiegert, O, Joels, M & Krugers, HJ 2007, Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective. in ER DeKloet & E Vermetten (eds), STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES. Progress in Brain Research, vol. 167, ELSEVIER SCIENCE BV, pp. 269-271, Colloquium on Stress Hormones and Post Traumatic Stress Disorder - Basic Studies and Clinical Perspectives, Amsterdam, Netherlands, 28/08/2006. https://doi.org/10.1016/S0079-6123(07)67021-6

Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective. / Wiegert, Olof; Joels, Marian; Krugers, Harm J.
STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES. ed. / ER DeKloet; E Vermetten. ELSEVIER SCIENCE BV, 2007. p. 269-271 (Progress in Brain Research; Vol. 167).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

TY - CHAP

T1 - Corticosteroid hormones, synaptic strength and emotional memories

T2 - Colloquium on Stress Hormones and Post Traumatic Stress Disorder - Basic Studies and Clinical Perspectives

AU - Wiegert, Olof

AU - Joels, Marian

AU - Krugers, Harm J.

PY - 2007

Y1 - 2007

N2 - Emotionally loaded and stressful events modulate cognitive performance. This modulation of cognitive performance is at least partially dependent on corticosteroid hormones that are released in high amounts during emotional or stressful events. Corticosterone both strengthens and suppresses cognitive performance and synaptic plasticity. These effects may critically depend on the timing of the stressful event and corticosteroid exposure with respect to the learning situation. Based on recent findings we propose a model in which corticosterone can rapidly enhance synaptic plasticity. Later, corticosterone may stabilize synaptic efficacy, possibly at the expense of reduced synaptic plasticity.

AB - Emotionally loaded and stressful events modulate cognitive performance. This modulation of cognitive performance is at least partially dependent on corticosteroid hormones that are released in high amounts during emotional or stressful events. Corticosterone both strengthens and suppresses cognitive performance and synaptic plasticity. These effects may critically depend on the timing of the stressful event and corticosteroid exposure with respect to the learning situation. Based on recent findings we propose a model in which corticosterone can rapidly enhance synaptic plasticity. Later, corticosterone may stabilize synaptic efficacy, possibly at the expense of reduced synaptic plasticity.

KW - RECEPTOR TRAFFICKING

KW - HIPPOCAMPAL

KW - POTENTIATION

KW - PLASTICITY

U2 - 10.1016/S0079-6123(07)67021-6

DO - 10.1016/S0079-6123(07)67021-6

M3 - Chapter

SN - 978-0-444-53140-7

T3 - Progress in Brain Research

SP - 269

EP - 271

BT - STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES

A2 - DeKloet, ER

A2 - Vermetten, E

PB - ELSEVIER SCIENCE BV

Y2 - 28 August 2006 through 30 August 2006

ER -

Wiegert O, Joels M, Krugers HJ. Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective. In DeKloet ER, Vermetten E, editors, STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES. ELSEVIER SCIENCE BV. 2007. p. 269-271. (Progress in Brain Research). doi: 10.1016/S0079-6123(07)67021-6

Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective

Abstract

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