Corticosterone modifies muscarinic receptor immunoreactivity in rat hippocampus

B R K Douma, K Jansen, S M Korte, B Buwalda, E A Van der Zee, P G M Luiten

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Abstract

In the present study we report the effect of corticosterone in the regulation of hippocampal muscarinic acetylcholine receptor immunoreactivity (mAChR-ir) expression in rats. Adrenalectomy (ADX) or a single injection of a mineralocorticoid antagonist RU-28318 (1.0 mg/100 g body weight (b.w.)) in adrenally intact rats 24 h prior to sacrifice revealed an increased mAChR-ir in hippocampal CA1 and CA3 areas. Corticosterone replacement (100 mu g/100 g b.w.) prevented the increase in mAChR-ir of ADX animals. However, glucocorticoid receptor antagonist (RU38486) treatment in adrenally intact rats failed to affect the mAChR immunolabeling, These results point to a modulation of muscarinic receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Volume268
Issue number1
DOIs
Publication statusPublished - 11-Jun-1999

Keywords

  • muscarinic receptor
  • adrenalectomy
  • corticosterone
  • glucocorticoid antagonist
  • mineralocorticoid antagonist
  • ANTAGONISTS
  • MODULATION
  • BLOCKADE
  • SYSTEM
  • STRESS

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