Costs and effects of chlamydial screening: Dynamic versus static modeling

R. Welte, Maarten Postma, R. Leidl, M. Kretzschmar

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

Objective: The objective of this study was to assess the impact of modeling type on the economic evaluation of screening programs for asymptomatic Chlamydia trachomatis infections.

Study: We compared a stochastic network simulation model (dynamic model) with a decision analysis model (static model) for estimating the cost-effectiveness of an opportunistic screening program. The influence of the model type on the required data, the computed results, and the sensitivity of model parameters were investigated.

Results: When compared with static modeling, dynamic modeling yielded different cost-effectiveness ratios and identified other optimal screening strategies as it considers changes in the force of infection caused by screening. However, it is more complex, data- and time-demanding, and more sensitive to some parameters affecting the force of infection than static modeling.

Conclusions: Dynamic models should be applied for the economic evaluation of prevention measures that have the potential to lower the force of infection such as large-scale chlamydial screening programs.

Original languageEnglish
Pages (from-to)474-483
Number of pages10
JournalSexually Transmitted Diseases
Volume32
Issue number8
DOIs
Publication statusPublished - Aug-2005

Keywords

  • PELVIC-INFLAMMATORY-DISEASE
  • VACCINATION PROGRAMS
  • ECONOMIC-EVALUATION
  • HERD-IMMUNITY
  • TRACHOMATIS
  • INFECTION
  • PREVENTION
  • GONORRHEA
  • PERSPECTIVE
  • STRATEGIES

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