Abstract
By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.
| Original language | English |
|---|---|
| Article number | 1340007 |
| Number of pages | 21 |
| Journal | Journal of Bioinformatics and Computational Biology |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb-2013 |
Keywords
- Transcription factors
- DNA-binding domains
- classification
- CRYSTAL-STRUCTURE
- STRUCTURAL BASIS
- COMPLEX REVEALS
- GLUCOCORTICOID-RECEPTOR
- PROTOONCOGENE PRODUCT
- TEA DOMAIN
- PROTEIN
- RECOGNITION
- BOX
- SEQUENCE