Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

Hugo Helbert, Ines Farinha Antunes, Gert Luurtsema, Wiktor Szymanski, Ben L Feringa*, Philip H Elsinga*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

3 Citations (Scopus)
39 Downloads (Pure)

Abstract

The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalChemical communications (Cambridge, England)
Volume57
Issue number2
Early online date26-Dec-2020
DOIs
Publication statusPublished - 7-Jan-2021

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