Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

Hugo Helbert; Ines Farinha Antunes; Gert Luurtsema; Wiktor Szymanski; Ben L Feringa; Philip H Elsinga

doi:10.1039/d0cc05392a

Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

Hugo Helbert, Ines Farinha Antunes, Gert Luurtsema, Wiktor Szymanski, Ben L Feringa, Philip H Elsinga

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging.

Original language	English
Pages (from-to)	203-206
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	57
Issue number	2
DOIs	https://doi.org/10.1039/d0cc05392a
Publication status	Published - 7-Jan-2021

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Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis
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AU - Feringa, Ben L

AU - Elsinga, Philip H

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AB - The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging.

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