Cross-disorder and disorder-specific deficits in social functioning among schizophrenia and Alzheimer's disease patients

Ilja M J Saris*, Moji Aghajani, Niels Jongs, Lianne M Reus, Nic J A van der Wee, Amy C Bilderbeck, Inge Winter van Rossum, Celso Arango, Alejandro de la Torre-Luque, Asad Malik, Andreea Raslescu, Gerard R Dawson, José L Ayuso-Mateos, Martien J Kas, Brenda W J H Penninx

*Corresponding author for this work

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Abstract

BACKGROUND: Social functioning is often impaired in schizophrenia (SZ) and Alzheimer's disease (AD). However, commonalities and differences in social dysfunction among these patient groups remain elusive.

MATERIALS AND METHODS: Using data from the PRISM study, behavioral (all subscales and total score of the Social Functioning Scale) and affective (perceived social disability and loneliness) indicators of social functioning were measured in patients with SZ (N = 56), probable AD (N = 50) and age-matched healthy controls groups (HC, N = 29 and N = 28). We examined to what extent social functioning differed between disease and age-matched HC groups, as well as between patient groups. Furthermore, we examined how severity of disease and mood were correlated with social functioning, irrespective of diagnosis.

RESULTS: As compared to HC, both behavioral and affective social functioning seemed impaired in SZ patients (Cohen's d's 0.81-1.69), whereas AD patients mainly showed impaired behavioral social function (Cohen's d's 0.65-1.14). While behavioral indices of social functioning were similar across patient groups, SZ patients reported more perceived social disability than AD patients (Cohen's d's 0.65). Across patient groups, positive mood, lower depression and anxiety levels were strong determinants of better social functioning (p's <0.001), even more so than severity of disease.

CONCLUSIONS: AD and SZ patients both exhibit poor social functioning in comparison to age- and sex matched HC participants. Social dysfunction in SZ patients may be more severe than in AD patients, though this may be due to underreporting by AD patients. Across patients, social functioning appeared as more influenced by mood states than by severity of disease.

Original languageEnglish
Article numbere0263769
Number of pages16
JournalPLoS ONE
Volume17
Issue number4
DOIs
Publication statusPublished - 14-Apr-2022

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