Crosstalk of the mTOR network with stress granules and the TGF-beta pathway

Mirja Tamara Prentzell

    Research output: ThesisThesis fully internal (DIV)

    911 Downloads (Pure)

    Abstract

    All organisms and cells need nutrients in order to grow and survive. The protein kinase mTOR (mechanistic or mammalian target of rapamycin) is a signaling hub that senses nutrients and promotes cell growth in all eukaryotes. mTOR is embedded in a complex signaling network whose dysregulation leads to severe malfunction and a variety of diseases, including cancer and neurological disorders.

    This thesis centers on mechanisms of mTOR crosstalk with two other cellular signaling networks governing cellular growth and survival. The first aim of this thesis was to characterize the interplay between mTOR and stress granules, cytoplasmic non-membranous RNA-protein assemblies. Stress granules are dynamic entities, which form upon stresses that arrest protein synthesis. The second aim was to unravel mTOR’s crosstalk with the transforming growth factor beta (TGF-beta) pathway. TGF-beta has key roles in organismal development and cancer by controlling processes such as cell proliferation, survival and migration.

    Our findings suggest that mTOR crosstalk with stress granules and the TGF-beta pathway influences the effects of drugs targeting the mTOR network, warranting further investigation in the context of targeted cancer therapies.
    Translated title of the contributionWisselwerkingen tussen het mTOR netwerk met stress granules en de TGF-beta signaleringsroute
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Thedieck, Kathrin, Supervisor
    • Baumeister, Ralf, Supervisor, External person
    • Opitz, C, Supervisor, External person
    • Baumeister, Ralf, Assessment committee, External person
    • Opitz, C, Assessment committee, External person
    • Foijer, Floris, Assessment committee
    • Sers, Christine, Assessment committee, External person
    Award date7-May-2018
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-034-0632-9
    Electronic ISBNs978-94-034-0631-2
    Publication statusPublished - 2018

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