Abstract
PnuC transporters catalyze cellular uptake of the NAD(+) precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3 + 1 + 3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.
| Original language | English |
|---|---|
| Pages (from-to) | 1013-1015 |
| Number of pages | 3 |
| Journal | Nature Structural & Molecular Biology |
| Volume | 21 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 7-Oct-2014 |
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