CSF hypocretin-1 levels are normal in multiple-system atrophy

W.F. Abdo; B.R. Bloem; H.P.H. Kremer; G.J. Lammers; M.M. Verbeek; S. Overeem

doi:10.1016/j.parkreldis.2007.08.012

CSF hypocretin-1 levels are normal in multiple-system atrophy

W.F. Abdo
, B.R. Bloem
, H.P.H. Kremer
, G.J. Lammers
, M.M. Verbeek
, S. Overeem

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.

Original language	English
Pages (from-to)	342-344
Number of pages	3
Journal	Parkinsonism & Related Disorders
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.parkreldis.2007.08.012
Publication status	Published - May-2008
Externally published	Yes

Keywords

Aged
Case-Control Studies
Female
Humans
Intracellular Signaling Peptides and Proteins
Male
Middle Aged
Multiple System Atrophy
Neuropeptides
Orexins
Journal Article
Research Support, Non-U.S. Gov't

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title = "CSF hypocretin-1 levels are normal in multiple-system atrophy",

abstract = "Sleep disturbances occur in 70\% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.",

keywords = "Aged, Case-Control Studies, Female, Humans, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, Multiple System Atrophy, Neuropeptides, Orexins, Journal Article, Research Support, Non-U.S. Gov't",

author = "W.F. Abdo and B.R. Bloem and H.P.H. Kremer and G.J. Lammers and M.M. Verbeek and S. Overeem",

year = "2008",

month = may,

doi = "10.1016/j.parkreldis.2007.08.012",

language = "English",

volume = "14",

pages = "342--344",

journal = "Parkinsonism \& Related Disorders",

issn = "1353-8020",

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}

TY - JOUR

T1 - CSF hypocretin-1 levels are normal in multiple-system atrophy

AU - Abdo, W.F.

AU - Bloem, B.R.

AU - Kremer, H.P.H.

AU - Lammers, G.J.

AU - Verbeek, M.M.

AU - Overeem, S.

PY - 2008/5

Y1 - 2008/5

N2 - Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.

AB - Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.

KW - Aged

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Male

KW - Middle Aged

KW - Multiple System Atrophy

KW - Neuropeptides

KW - Orexins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.parkreldis.2007.08.012

DO - 10.1016/j.parkreldis.2007.08.012

M3 - Article

C2 - 17977056

SN - 1353-8020

VL - 14

SP - 342

EP - 344

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

IS - 4

ER -

CSF hypocretin-1 levels are normal in multiple-system atrophy

Abstract

Keywords

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