CSF Neurofilament Proteins Levels are Elevated in Sporadic Creutzfeldt-Jakob Disease

Jeroen J. J. van Eijk, Bart van Everbroeck, W. Farid Abdo, Berry P. H. Kremer, Marcel M. Verbeek*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    30 Citations (Scopus)

    Abstract

    In this study we investigated the cerebrospinal fluid (CSF) levels of neurofilament light (NFL) and heavy chain (NFHp35), total tau (t-tau), and glial fibrillary acidic protein (GFAP) to detect disease specific profiles in sporadic Creutzfeldt Jakob disease (sCJD) patients and Alzheimer's disease (AD) patients. CSF levels of NFL, NFHp35, t-tau, and GFAP of 23 sCJD patients and 55 AD patients were analyzed and compared to non-demented controls. Median NFL, NFHp35, GFAP, and t-tau levels were significantly increased in sCJD patients and AD patients versus controls (p <0.0001 in all). NFL, NFHp35, and t-tau levels were significantly increased in sCJD patients versus AD patients (p <0.005), but GFAP concentrations did not differ between sCJD and AD. The results suggest that neuroaxonal damage, reflected by higher CSF levels of NFL, NFHp35, and t-tau, is more pronounced in the pathophysiology of sCJD than in AD. The comparable CSF GFAP concentrations suggest that astroglial damage or astrocytosis is equally pronounced in the pathophysiology of AD and sCJD. Prospective studies are needed to determine whether NFL and NFHp35 may be additional tools in the differential diagnosis of rapidly progressive dementias.

    Original languageEnglish
    Pages (from-to)569-576
    Number of pages8
    JournalJournal of alzheimers disease
    Volume21
    Issue number2
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Alzheimer's disease
    • cerebrospinal fluid
    • Creutzfeldt-Jakob disease
    • diagnosis
    • prion disease
    • NEURON-SPECIFIC ENOLASE
    • CEREBROSPINAL-FLUID
    • ALZHEIMERS-DISEASE
    • DIFFERENTIAL-DIAGNOSIS
    • S-100 PROTEIN
    • DEMENTIA
    • TESTS

    Cite this