Cu(ii)-Catalysed β-silylation of dehydroalanine residues in peptides and proteins

Reinder H de Vries, Gerard Roelfes

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Abstract

We report the efficient and selective Cu(ii)-catalysed β-silylation of naturally occurring dehydroalanine (Dha) residues in various ribosomally synthesized and post-translationally modified peptides (RiPPs). The method is also applicable to proteins, as was shown by the modification of a Dha residue that was chemically introduced into Small Ubiquitin-like Modifier (SUMO).

Original languageEnglish
Pages (from-to)11058-11061
Number of pages4
JournalChemical communications (Cambridge, England)
Volume56
Issue number75
Early online date19-Aug-2020
DOIs
Publication statusPublished - 25-Sep-2020

Keywords

  • SILICON-CONTAINING PEPTIDES
  • ALPHA-AMINO-ACIDS
  • BIOLOGICAL-ACTIVITY
  • NATURAL-PRODUCTS
  • DIVERGENT
  • BOND

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