Current treatment options for recurrent nasopharyngeal cancer

Carlos Suarez, Juan P. Rodrigo, Alessandra Rinaldo, Johannes A. Langendijk, Ashok R. Shaha, Alfio Ferlito*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

98 Citations (Scopus)

Abstract

Loco-regional control rate of nasopharyngeal carcinoma (NPC) has improved significantly in the past decade. However, local recurrence still represents a major cause of mortality and morbidity in advanced stages, and management of local failure remains a challenging issue in NPC. The best salvage treatment for local recurrent NPC remains to be determined. The options include brachytherapy, external radiotherapy, stereotactic radiosurgery, and nasopharyngectomy, either alone or in different combinations. In this article we will discuss the different options for salvage of locally recurrent NPC. Retreatment of locally recurrent NPC using radiotherapy, alone or in combination with other treatment modalities, as well as surgery, can result in long-term local control and survival in a substantial proportion of patients. For small-volume recurrent tumors (T1-T2) treated with external radiotherapy, brachytherapy or stereotactic radiosurgery, comparable results to those obtained with surgery have been reported. In contrast, treatment results of advanced-stage locally recurrent NPC are generally more satisfactory with surgery (with or without postoperative radiotherapy) than with reirradiation.

Original languageEnglish
Pages (from-to)1811-1824
Number of pages14
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume267
Issue number12
DOIs
Publication statusPublished - Dec-2010

Keywords

  • Nasopharyngeal carcinoma
  • Recurrent
  • Radiotherapy
  • Brachytherapy
  • Nasopharyngectomy
  • INTENSITY-MODULATED RADIOTHERAPY
  • POSITRON-EMISSION-TOMOGRAPHY
  • 3-DIMENSIONAL CONFORMAL RADIOTHERAPY
  • FACIAL TRANSLOCATION APPROACH
  • SALVAGING LOCAL FAILURES
  • GOLD GRAIN IMPLANTATION
  • LONG-TERM SURVIVAL
  • RADIATION-THERAPY
  • STEREOTACTIC RADIOSURGERY
  • SKULL BASE

Cite this