Curvature-Induced Sorting of Lipids in Plasma Membrane Tethers

Svetlana Baoukina, Helgi I. Ingolfsson, Siewert J. Marrink, D. Peter Tieleman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

Membrane curvature controls the spatial organization and activity of cells. Lipid sorting in cell membranes can be explained by matching lipid molecular shape to regions of different curvatures. A molecular view of curvature-induced lipid sorting is obtained using coarse-grained molecular dynamics. A model membrane consisting of an asymmetric bilayer of multiple lipid species is simulated. Curvature is induced by pulling a tether, that is, a bilayer nanotube, from a flat membrane. Pulling is performed both from the inner and outer leaflets, corresponding to directions in and out of the cell. Redistribution of different lipid types between the tether and the bilayer is observed, leading to spatial variations in the composition of both leaflets, and, in turn, softening of the tether. Depending on the direction of pulling, the lipid distributions and the tether properties differ. Formation of a tether from the planar membrane thus induces lipid sorting without phase separation.

Original languageEnglish
Article number1800034
Number of pages4
JournalAdvanced theory and simulations
Volume1
Issue number8
DOIs
Publication statusPublished - Aug-2018

Keywords

  • bilayer nanotubes
  • cellulartrafficking
  • curvature sensing
  • molecular shape
  • transport intermediates
  • FORCE-FIELD
  • PROTEINS
  • MECHANISMS
  • ORGANIZATION
  • SEGREGATION
  • FISSION
  • MARTINI

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