Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp

A Banerjee, AS Banks, MC Nawijn, XP Chen, PB Rothman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Abstract

Recent studies have suggested that signaling initiated by the activation of Ag receptors and signaling activated through cytokine receptors may be regulated by a common set of inhibitory proteins. Suppressor of cytokine signaling 3 (SOCS-3), which has previously been demonstrated to inhibit cytokine signaling, is induced on TCR ligation. Overexpression of SOCS-3 can inhibit transcription driven by the IL-2 promoter in response to T cell activation. This inhibitory activity correlates with the suppression of calcineurin-dependent dephosphorylation and activation of the IL-2 promoter binding transcription factor, NFATp. Infection of primary marine T cells with a retrovirus encoding SOCS-3 blocks their IL-2 production in response to activation. Interestingly, SOCS-3 was found to coimmunoprecipitate with the catalytic subunit of calcineurin. These studies suggest that SOCS-3 may regulate T cell function as part of a negative feedback loop.

Original languageEnglish
Pages (from-to)4277-4281
Number of pages5
JournalJournal of Immunology
Volume168
Issue number9
Publication statusPublished - 1-May-2002

Keywords

  • IMMUNE-SYSTEM
  • T-CELLS
  • NF-AT
  • PROLIFERATION
  • PROTEIN
  • INTERLEUKIN-2
  • EXPRESSION
  • SURVIVAL
  • KINASES
  • SOCS-3

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