Cycloruthenated compounds as efficient catalyst for asymmetric hydride transfer reaction

Jean-Baptiste Sortais, Laurent Barloy, Claude Sirlin, André H.M. de Vries, Johannes G. de Vries, Michel Pfeffer

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Cycloruthenated complexes obtained by direct C–H activation of enantiopure aromatic primary and secondary amines are efficient catalysts in asymmetric hydride transfer reaction. Reduction of acetophenone has been achieved rapidly with enantiomeric excesses (ee’s) ranging from 38 to 89 %. The importance of Ru–C bond in the catalytic efficiency is highlighted.
Original languageEnglish
Pages (from-to)457-462
Number of pages6
JournalPure and Applied Chemistry
Issue number2
Publication statusPublished - 2006


  • ruthenium
  • amines
  • catalysis
  • reduction
  • high-throughput experiments
  • ketones
  • enantioselectivity
  • chirality
  • cyclometallation

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