CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

Anne B. Koopmans*, David J. Vinkers, Petra J. A. Gelan, Hans W. Hoek, Peter N. van Harten

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. 

    Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curacao and 166 were volunteers from the Dutch Caribbean population. 

    Results: No differences in prevalence of alleles were found. 

    Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.

    Original languageEnglish
    Pages (from-to)1003-1012
    Number of pages10
    JournalPharmacogenomics
    Volume18
    Issue number10
    DOIs
    Publication statusPublished - 1-Jul-2017

    Keywords

    • Caribbean
    • CYP2C19
    • CYP2D6
    • ethnicity
    • prevalence
    • psychiatry
    • DEBRISOQUINE 4-HYDROXYLASE CYP2D6
    • GENETIC POLYMORPHISMS
    • TARDIVE-DYSKINESIA
    • HEALTHY-VOLUNTEERS
    • COST-EFFECTIVENESS
    • ALLELE FREQUENCY
    • SCHIZOPHRENIA
    • CYTOCHROME-P450
    • PHARMACOGENETICS
    • IMPLEMENTATION

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