Abstract
The invention relates compositions and methods of prolonging the lifespan of a subject or providing anti-aging benefits. A method of the invention comprises administering an agent that inhibits the conversion of cysteine to cysteine sulfinic acid to a subject, for example using an inhibitor of cysteine dioxygenase (CDO). A composition of the invention may comprise a) a CDO inhibitor; and b) a second agent known to be useful in prolonging the lifespan of a subject or preventing or reducing age-related symptoms. Also provided is a CDO-based screening method for identifying a compound capable of prolonging the lifespan of a subject or preventing or reducing age-related symptoms in a subject.
| Original language | English |
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| Patent number | EP3251664 |
| Priority date | 02/06/2016 |
| Publication status | Published - 6-Dec-2017 |