CYTOGENETICS AS A TOOL IN THE HISTOLOGIC SUBCLASSIFICATION OF CHONDROSARCOMAS

T DIJKHUIZEN; E VANDENBERG; WM MOLENAAR; JW OOSTERHUIS; J WIERSEMA; HS KOOPS; B DEJONG; A. Dam

CYTOGENETICS AS A TOOL IN THE HISTOLOGIC SUBCLASSIFICATION OF CHONDROSARCOMAS

T DIJKHUIZEN^*
, E VANDENBERG
, WM MOLENAAR
, JW OOSTERHUIS
, J WIERSEMA
, HS KOOPS
, B DEJONG
, A. Dam

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

Abstract

Chondrosarcomas are a heterogeneous group of bone neoplasms of which the basic neoplastic tissue is cartilaginous. Frequently the histologic diagnosis and grading of chondrosarcomas is difficult and the histologic appearance does not always reflect the biologic behavior of these rumors. Therefore, it is important to find other parameters that can be of help in the proper diagnosing and grading of these neoplasms. To this end, we attempted to correlate the chromosomal pattern of chondrosarcomas to their histologic subtypes and grades. The cytogenetic analysis of two intermediate-grade chondrosarcomas of bone, and a review of the literature, are presented.

Original language	English
Pages (from-to)	100-105
Number of pages	6
Journal	Cancer Genetics and Cytogenetics
Volume	76
Issue number	2
Publication status	Published - Sept-1994

Keywords

MYXOID CHONDROSARCOMA
DNA CONTENT
REARRANGEMENTS
TUMORS
TRANSLOCATION
CHROMOSOME-22
COMPLEX
BENIGN

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title = "CYTOGENETICS AS A TOOL IN THE HISTOLOGIC SUBCLASSIFICATION OF CHONDROSARCOMAS",

abstract = "Chondrosarcomas are a heterogeneous group of bone neoplasms of which the basic neoplastic tissue is cartilaginous. Frequently the histologic diagnosis and grading of chondrosarcomas is difficult and the histologic appearance does not always reflect the biologic behavior of these rumors. Therefore, it is important to find other parameters that can be of help in the proper diagnosing and grading of these neoplasms. To this end, we attempted to correlate the chromosomal pattern of chondrosarcomas to their histologic subtypes and grades. The cytogenetic analysis of two intermediate-grade chondrosarcomas of bone, and a review of the literature, are presented.",

keywords = "MYXOID CHONDROSARCOMA, DNA CONTENT, REARRANGEMENTS, TUMORS, TRANSLOCATION, CHROMOSOME-22, COMPLEX, BENIGN",

author = "T DIJKHUIZEN and E VANDENBERG and WM MOLENAAR and JW OOSTERHUIS and J WIERSEMA and HS KOOPS and B DEJONG and A. Dam",

year = "1994",

month = sep,

language = "English",

volume = "76",

pages = "100--105",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "ELSEVIER SCIENCE INC",

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TY - JOUR

T1 - CYTOGENETICS AS A TOOL IN THE HISTOLOGIC SUBCLASSIFICATION OF CHONDROSARCOMAS

AU - DIJKHUIZEN, T

AU - VANDENBERG, E

AU - MOLENAAR, WM

AU - OOSTERHUIS, JW

AU - WIERSEMA, J

AU - KOOPS, HS

AU - DEJONG, B

AU - Dam, A.

PY - 1994/9

Y1 - 1994/9

N2 - Chondrosarcomas are a heterogeneous group of bone neoplasms of which the basic neoplastic tissue is cartilaginous. Frequently the histologic diagnosis and grading of chondrosarcomas is difficult and the histologic appearance does not always reflect the biologic behavior of these rumors. Therefore, it is important to find other parameters that can be of help in the proper diagnosing and grading of these neoplasms. To this end, we attempted to correlate the chromosomal pattern of chondrosarcomas to their histologic subtypes and grades. The cytogenetic analysis of two intermediate-grade chondrosarcomas of bone, and a review of the literature, are presented.

AB - Chondrosarcomas are a heterogeneous group of bone neoplasms of which the basic neoplastic tissue is cartilaginous. Frequently the histologic diagnosis and grading of chondrosarcomas is difficult and the histologic appearance does not always reflect the biologic behavior of these rumors. Therefore, it is important to find other parameters that can be of help in the proper diagnosing and grading of these neoplasms. To this end, we attempted to correlate the chromosomal pattern of chondrosarcomas to their histologic subtypes and grades. The cytogenetic analysis of two intermediate-grade chondrosarcomas of bone, and a review of the literature, are presented.

KW - MYXOID CHONDROSARCOMA

KW - DNA CONTENT

KW - REARRANGEMENTS

KW - TUMORS

KW - TRANSLOCATION

KW - CHROMOSOME-22

KW - COMPLEX

KW - BENIGN

M3 - Article

SN - 0165-4608

VL - 76

SP - 100

EP - 105

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

CYTOGENETICS AS A TOOL IN THE HISTOLOGIC SUBCLASSIFICATION OF CHONDROSARCOMAS

Abstract

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