Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

Luigi Messori*, Angela Casini, Chiara Gabbiani, Elena Michelucci, Leticia Cubo, Carla Rios-Luci, Jose M. Padron, Carmen Navarro-Ranninger, Adoracion G. Quiroga

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Abstract

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Volume1
Issue number8
DOIs
Publication statusPublished - Nov-2010
Externally publishedYes

Keywords

  • Iodidoplatinum complex
  • cytotoxicity
  • DNA and protein interaction
  • METALLODRUG-PROTEIN INTERACTIONS
  • PLATINUM ANTITUMOR DRUGS
  • HEART CYTOCHROME-C
  • MASS-SPECTROMETRY
  • DNA
  • ESI
  • PLATINATION
  • COMPOUND
  • INSIGHTS
  • PYRIDINE

Cite this