Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

Luigi Messori; Angela Casini; Chiara Gabbiani; Elena Michelucci; Leticia Cubo; Carla Rios-Luci; Jose M. Padron; Carmen Navarro-Ranninger; Adoracion G. Quiroga

doi:10.1021/ml100081e

Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

Luigi Messori^*, Angela Casini, Chiara Gabbiani, Elena Michelucci, Leticia Cubo, Carla Rios-Luci, Jose M. Padron, Carmen Navarro-Ranninger, Adoracion G. Quiroga

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Abstract

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

Original language	English
Pages (from-to)	381-385
Number of pages	5
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	1
Issue number	8
DOIs	https://doi.org/10.1021/ml100081e
Publication status	Published - Nov-2010
Externally published	Yes

Keywords

Iodidoplatinum complex
cytotoxicity
DNA and protein interaction
METALLODRUG-PROTEIN INTERACTIONS
PLATINUM ANTITUMOR DRUGS
HEART CYTOCHROME-C
MASS-SPECTROMETRY
DNA
ESI
PLATINATION
COMPOUND
INSIGHTS
PYRIDINE

Access to Document

10.1021/ml100081e

Cite this

Messori, Luigi ; Casini, Angela ; Gabbiani, Chiara ; Michelucci, Elena ; Cubo, Leticia ; Rios-Luci, Carla ; Padron, Jose M. ; Navarro-Ranninger, Carmen ; Quiroga, Adoracion G. / Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex. In: Bioorganic & Medicinal Chemistry Letters. 2010 ; Vol. 1, No. 8. pp. 381-385.

@article{345d4c5543de4baa8b398e7e8490b812,

title = "Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel {"}Rule-Breaker{"} Iodidoplatinum(II) Complex",

abstract = "Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.",

keywords = "Iodidoplatinum complex, cytotoxicity, DNA and protein interaction, METALLODRUG-PROTEIN INTERACTIONS, PLATINUM ANTITUMOR DRUGS, HEART CYTOCHROME-C, MASS-SPECTROMETRY, DNA, ESI, PLATINATION, COMPOUND, INSIGHTS, PYRIDINE",

author = "Luigi Messori and Angela Casini and Chiara Gabbiani and Elena Michelucci and Leticia Cubo and Carla Rios-Luci and Padron, {Jose M.} and Carmen Navarro-Ranninger and Quiroga, {Adoracion G.}",

year = "2010",

month = nov,

doi = "10.1021/ml100081e",

language = "English",

volume = "1",

pages = "381--385",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "American Chemical Society",

number = "8",

}

Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex. / Messori, Luigi; Casini, Angela; Gabbiani, Chiara; Michelucci, Elena; Cubo, Leticia; Rios-Luci, Carla; Padron, Jose M.; Navarro-Ranninger, Carmen; Quiroga, Adoracion G.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 1, No. 8, 11.2010, p. 381-385.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

AU - Messori, Luigi

AU - Casini, Angela

AU - Gabbiani, Chiara

AU - Michelucci, Elena

AU - Cubo, Leticia

AU - Rios-Luci, Carla

AU - Padron, Jose M.

AU - Navarro-Ranninger, Carmen

AU - Quiroga, Adoracion G.

PY - 2010/11

Y1 - 2010/11

N2 - Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

AB - Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

KW - Iodidoplatinum complex

KW - cytotoxicity

KW - DNA and protein interaction

KW - METALLODRUG-PROTEIN INTERACTIONS

KW - PLATINUM ANTITUMOR DRUGS

KW - HEART CYTOCHROME-C

KW - MASS-SPECTROMETRY

KW - DNA

KW - ESI

KW - PLATINATION

KW - COMPOUND

KW - INSIGHTS

KW - PYRIDINE

U2 - 10.1021/ml100081e

DO - 10.1021/ml100081e

M3 - Article

VL - 1

SP - 381

EP - 385

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 8

ER -