D-serine in the developing human central nervous system

Sabine A Fuchs, Lambertus Dorland, Monique G de Sain-van der Velden, Margriet Hendriks, Leo W J Klomp, Ruud Berger, Tom J de Koning

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To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development.

Original languageEnglish
Pages (from-to)476-80
Number of pages5
JournalAnnals of Neurology
Issue number4
Publication statusPublished - 2006
Externally publishedYes


  • Central Nervous System
  • Child
  • Child, Preschool
  • Female
  • Glycine
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neuronal Plasticity
  • Phosphoglycerate Dehydrogenase
  • Serine
  • Stereoisomerism
  • Journal Article
  • Research Support, Non-U.S. Gov't

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