Abstract
To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development.
Original language | English |
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Pages (from-to) | 476-80 |
Number of pages | 5 |
Journal | Annals of Neurology |
Volume | 60 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2006 |
Externally published | Yes |
Keywords
- Central Nervous System
- Child
- Child, Preschool
- Female
- Glycine
- Humans
- Infant
- Infant, Newborn
- Male
- Neuronal Plasticity
- Phosphoglycerate Dehydrogenase
- Serine
- Stereoisomerism
- Journal Article
- Research Support, Non-U.S. Gov't