Daily light exposure patterns reveal phase and period of the human circadian clock

Tom Woelders, Domien G M Beersma, Marijke C M Gordijn, Roelof A Hut, Emma J Wams

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Abstract

Light is the most potent time cue that synchronizes (entrains) the circadian pacemaker to the 24-h solar cycle. This entrainment process is an interplay between an individual's daily light perception and intrinsic pacemaker period under free-running conditions. Establishing individual estimates of circadian phase and period can be time-consuming. We show that circadian phase can be accurately predicted (SD = 1.1 h for dim light melatonin onset, DLMO) using 9 days of ambulatory light and activity data as an input to Kronauer's limit-cycle model for the human circadian system. This approach also yields an estimated circadian period of 24.2 h (SD = 0.2 h), with longer periods resulting in later DLMOs. A larger amount of daylight exposure resulted in an earlier DLMO. Individuals with a long circadian period also showed shorter intervals between DLMO and sleep timing. When a field-based estimation of tau can be validated under laboratory studies in a wide variety of individuals, the proposed methods may prove to be essential tools for individualized chronotherapy and light treatment for shift work and jetlag applications. These methods may improve our understanding of fundamental properties of human circadian rhythms under daily living conditions.

Original languageEnglish
Pages (from-to)274-286
Number of pages13
JournalJournal of Biological Rhythms
Volume32
Issue number3
DOIs
Publication statusPublished - Jun-2017

Keywords

  • light
  • activity
  • ambulatory
  • circadian pacemaker
  • tau
  • intrinsic period
  • DLMO
  • CBT
  • core body temperature
  • modeling
  • MATHEMATICAL-MODEL
  • MORNINGNESS-EVENINGNESS
  • INTRINSIC PERIOD
  • PLASMA MELATONIN
  • BRIGHT LIGHT
  • DARK CYCLE
  • PACEMAKER
  • ENTRAINMENT
  • TEMPERATURE
  • RHYTHMS

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