DC Calcium lactate, a new filler-binder for direct compaction of tablets

GK Bolhuis*, AC Eissens, E Zoestbergen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

In this paper, a directly compressible form of calcium lactate is introduced as a filler-binder for direct compaction of tablets. Calcium lactate is one of the most important calcium sources and has, in comparison with other organic calcium salts, a good solubility and bioavailability. Two different modifications, calcium lactate trihydrate and calcium lactate pentahydrate are described in the main pharmacopoeias. This paper describes that the compaction properties of calcium lactate pentahydrate (Puracal (R) DC) are much better than those of the calcium lactate trihydrate (Puracal (R) TP). Calcium lactate pentahydrate has better compaction properties than dicalcium phosphate dihydrate, even if lubricated with magnesium stearate. Moreover, as a consequence of its crystalline structure, calcium lactate pentahydrate has a low compaction speed sensitivity. This means that, in combination with its excellent flow properties, calcium lactate pentahydrate is a suitable filler-binder in tablets prepared by high-speed compaction. In a number of formulation examples it will be illustrated that tablets containing calcium lactate pentahydrate as main or additional filler-binder have a short disintegration time and a fast drug release. Directly compressible calcium lactate can be considered as a promising excipient in both pharmaceutical tablets and tablets for the nutraceutical market. (C) 2001 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume221
Issue number1-2
Publication statusPublished - 19-Jun-2001

Keywords

  • tablet
  • direct compaction
  • filler-binder
  • calcium lactate
  • DISINTEGRATION
  • PHOSPHATES
  • LACTOSE

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