Abstract
Three cases of de novo acute B-cell lymphoblastic leukemia are presented, all with an unusual phenotype, involvement of translocation t(14;18) and additional chromosomal abnormalities, including translocation t(8;14) and deletion of chromosome 9. In contrast to normal FAB-L2 or FAB-L3 acute lymphoblastic leukemia (ALL), these leukemias did not express cytoplasmatic and membranous immunoglobulin. The combination of translocation t(14;18) and additional chromosomal events on the other chromosome 14 account for the lack of immunoglobulin expression. In one case a low grade follicular lymphoma was found next to a high grade Burkitt type ALL. The translocation t(14;18) takes place as a mistake in the VDJH joining in pre-B cells in the bone marrow. It is proposed that some cases of de novo ALL may arise as a blast crisis induced by genetic events, secondary to the primary t(14;18) translocation. This type of ALL seems to have a poor prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 473-8 |
| Number of pages | 6 |
| Journal | Leukemia |
| Volume | 5 |
| Issue number | 6 |
| Publication status | Published - Jun-1991 |
| Externally published | Yes |
Keywords
- Adult
- Antigens, CD
- Antigens, CD19
- Antigens, Differentiation
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Neoplasm
- Burkitt Lymphoma
- Cell Membrane
- Chromosome Deletion
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- Chromosomes, Human, Pair 8
- Chromosomes, Human, Pair 9
- Cytoplasm
- DNA Nucleotidylexotransferase
- Humans
- Immunoglobulins
- Immunophenotyping
- Lymphoma, Follicular
- Male
- Middle Aged
- Neprilysin
- Prognosis
- Translocation, Genetic