Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program

Angelique G S C Jansen, Elisabeth A M Sanders, Kristin L Nichol, Anton M van Loon, Arno W Hoes, Eelko Hak

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    With a retrospective nationwide cohort study in the Netherlands over 1992-2003, using mortality and viral surveillance data, the aim was to assess by means of rate difference methods the influenza-associated mortality in the elderly before and after the introduction of a nationwide influenza vaccination program in 1996 (vaccination coverage raised from below 50 to 80%). The average annual influenza-associated mortality declined in the years before and after the introduction from 131 to 105 per 100,000 persons (relative risk 0.80). The decline was largest in the age group 65-69 years (relative risk 0.54) and less in those aged 75 years and older. Validation by Serfling-type regression analysis revealed similar results. In conclusion, routine influenza vaccination among Dutch elderly was associated with a significant decrease in influenza-associated mortality, notably in those aged 65-69 years.

    Original languageEnglish
    Pages (from-to)5567-5574
    Number of pages8
    Issue number44
    Publication statusPublished - 16-Oct-2008


    • Age Distribution
    • Aged
    • Aged, 80 and over
    • Humans
    • Immunization Programs
    • Influenza A Virus, H3N2 Subtype
    • Influenza Vaccines
    • Influenza, Human
    • National Health Programs
    • Netherlands
    • Population Surveillance
    • Program Evaluation
    • Seasons

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