Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction

Kevin Damman; Gerjan Navis; Tom D. J. Smilde; Adriaan A. Voors; Wim van der Bij; Dirk J. van Veldhuisen; Hans L. Hillege

doi:10.1016/j.ejheart.2007.05.010

Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction

Kevin Damman, Gerjan Navis, Tom D. J. Smilde, Adriaan A. Voors, Wim van der Bij, Dirk J. van Veldhuisen, Hans L. Hillege^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

286 Citations (Scopus)

Abstract

Background: Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion.

Aims: To investigate the relationship between venous congestion and glomerular filtration rate (GFR) in patients with cardiac dysfunction.

Methods and results: Right atrial pressure (RAP) and cardiac index (CI) were determined by right heart catheterisation in 51 patients with cardiac dysfunction, secondary to pulmonary hypertension. GFR and renal blood flow (RBF) were measured as I-125-lothalamate and I-131- Hippuran clearances, respectively. Mean age was 40 +/- 11 years and 69% of patients were female. GFR was 73 +/- 19 ml/min/1.73 m(2) with a CI of 2.1 +/- 0.7 l/min/m(2). In multivariate analysis, RBF (r=0.664, p

Conclusion: RBF is the main factor determining GFR in patients with cardiac dysfunction. Venous congestion, characterised by an increased RAP, adjusted for RBF is also related to GFR. Treatment to preserve GFR should not only focus on improvement of renal perfusion, but also on decreasing venous congestion. (C) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	872-878
Number of pages	7
Journal	European Journal of Heart Failure
Volume	9
Issue number	9
DOIs	https://doi.org/10.1016/j.ejheart.2007.05.010
Publication status	Published - Sep-2007

Keywords

heart failure
renal function
kidney
haemodynamics
venous congestion
CHRONIC HEART-FAILURE
RENIN-ANGIOTENSIN SYSTEM
SYMPATHETIC-NERVES
KIDNEY-FUNCTION
MYOCARDIAL-INFARCTION
NEURAL-CONTROL
PRESSURE
INHIBITION
THERAPY
ULTRAFILTRATION

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10.1016/j.ejheart.2007.05.010

Cite this

@article{29074fa2ecdc48039a04c0578e053186,

title = "Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction",

abstract = "Background: Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion.Aims: To investigate the relationship between venous congestion and glomerular filtration rate (GFR) in patients with cardiac dysfunction.Methods and results: Right atrial pressure (RAP) and cardiac index (CI) were determined by right heart catheterisation in 51 patients with cardiac dysfunction, secondary to pulmonary hypertension. GFR and renal blood flow (RBF) were measured as I-125-lothalamate and I-131- Hippuran clearances, respectively. Mean age was 40 +/- 11 years and 69% of patients were female. GFR was 73 +/- 19 ml/min/1.73 m(2) with a CI of 2.1 +/- 0.7 l/min/m(2). In multivariate analysis, RBF (r=0.664, pConclusion: RBF is the main factor determining GFR in patients with cardiac dysfunction. Venous congestion, characterised by an increased RAP, adjusted for RBF is also related to GFR. Treatment to preserve GFR should not only focus on improvement of renal perfusion, but also on decreasing venous congestion. (C) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.",

keywords = "heart failure, renal function, kidney, haemodynamics, venous congestion, CHRONIC HEART-FAILURE, RENIN-ANGIOTENSIN SYSTEM, SYMPATHETIC-NERVES, KIDNEY-FUNCTION, MYOCARDIAL-INFARCTION, NEURAL-CONTROL, PRESSURE, INHIBITION, THERAPY, ULTRAFILTRATION",

author = "Kevin Damman and Gerjan Navis and Smilde, {Tom D. J.} and Voors, {Adriaan A.} and {van der Bij}, Wim and {van Veldhuisen}, {Dirk J.} and Hillege, {Hans L.}",

note = "Article 2",

year = "2007",

month = sep,

doi = "10.1016/j.ejheart.2007.05.010",

language = "English",

volume = "9",

pages = "872--878",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Wiley",

number = "9",

}

Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction. / Damman, Kevin ; Navis, Gerjan; Smilde, Tom D. J.; Voors, Adriaan A.; van der Bij, Wim ; van Veldhuisen, Dirk J.; Hillege, Hans L.

In: European Journal of Heart Failure, Vol. 9, No. 9, 09.2007, p. 872-878.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction

AU - Damman, Kevin

AU - Navis, Gerjan

AU - Smilde, Tom D. J.

AU - Voors, Adriaan A.

AU - van der Bij, Wim

AU - van Veldhuisen, Dirk J.

AU - Hillege, Hans L.

N1 - Article 2

PY - 2007/9

Y1 - 2007/9

N2 - Background: Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion.Aims: To investigate the relationship between venous congestion and glomerular filtration rate (GFR) in patients with cardiac dysfunction.Methods and results: Right atrial pressure (RAP) and cardiac index (CI) were determined by right heart catheterisation in 51 patients with cardiac dysfunction, secondary to pulmonary hypertension. GFR and renal blood flow (RBF) were measured as I-125-lothalamate and I-131- Hippuran clearances, respectively. Mean age was 40 +/- 11 years and 69% of patients were female. GFR was 73 +/- 19 ml/min/1.73 m(2) with a CI of 2.1 +/- 0.7 l/min/m(2). In multivariate analysis, RBF (r=0.664, pConclusion: RBF is the main factor determining GFR in patients with cardiac dysfunction. Venous congestion, characterised by an increased RAP, adjusted for RBF is also related to GFR. Treatment to preserve GFR should not only focus on improvement of renal perfusion, but also on decreasing venous congestion. (C) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

AB - Background: Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion.Aims: To investigate the relationship between venous congestion and glomerular filtration rate (GFR) in patients with cardiac dysfunction.Methods and results: Right atrial pressure (RAP) and cardiac index (CI) were determined by right heart catheterisation in 51 patients with cardiac dysfunction, secondary to pulmonary hypertension. GFR and renal blood flow (RBF) were measured as I-125-lothalamate and I-131- Hippuran clearances, respectively. Mean age was 40 +/- 11 years and 69% of patients were female. GFR was 73 +/- 19 ml/min/1.73 m(2) with a CI of 2.1 +/- 0.7 l/min/m(2). In multivariate analysis, RBF (r=0.664, pConclusion: RBF is the main factor determining GFR in patients with cardiac dysfunction. Venous congestion, characterised by an increased RAP, adjusted for RBF is also related to GFR. Treatment to preserve GFR should not only focus on improvement of renal perfusion, but also on decreasing venous congestion. (C) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

KW - heart failure

KW - renal function

KW - kidney

KW - haemodynamics

KW - venous congestion

KW - CHRONIC HEART-FAILURE

KW - RENIN-ANGIOTENSIN SYSTEM

KW - SYMPATHETIC-NERVES

KW - KIDNEY-FUNCTION

KW - MYOCARDIAL-INFARCTION

KW - NEURAL-CONTROL

KW - PRESSURE

KW - INHIBITION

KW - THERAPY

KW - ULTRAFILTRATION

U2 - 10.1016/j.ejheart.2007.05.010

DO - 10.1016/j.ejheart.2007.05.010

M3 - Article

VL - 9

SP - 872

EP - 878

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 9

ER -