Decreased vaccine antibody titers following exposure to multiple metals and metalloids in e-waste-exposed preschool children

Xinjiang Lin, Xijin Xu, Xiang Zeng, Long Xu, Zhijun Zeng, Xia Huo*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    31 Citations (Scopus)

    Abstract

    We explored acquired immunity resulting from vaccination in 3 to 7-year-old children, chronically exposed to multiple heavy metals and metalloids, in an e-waste recycling area (Guiyu, China). Child blood levels of ten heavy metals and metalloids, including lead (Pb), arsenic (As), mercury (Hg), chromium (Cr), cadmium (Cd), manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn) and selenium (Se), and seven vaccine antibodies (diphtheria, pertussis, tetanus, hepatitis B, Japanese encephalitis, polio, measles) were measured. The exposed group had higher levels of blood Pb, Mn, Cu, Zn and Cr compared to the reference group (P <0.05). Levels of all vaccine antibodies in the exposed group were significantly lower than in the reference group (P <0.01). All vaccine antibodies negatively correlated with blood concentrations of Cu, Zn and Pb, based on spearman rank correlation analysis. Multiple logistic regression and univariate analyses identified the location of residence (Guiyu), high blood Pb (>10 mu g/dL) and high blood Cu and Zn (upper median value of each group) to be inversely associated with seven antibody titers. Antibody titers increased with age, BMI, high blood Mn (>15 mu g/L), and high blood Cd and Ni (upper median value of each group). Results suggest multiple heavy metal and metalloid exposure, especially to Pb, Zn and Cu, may be a risk factor inhibiting the development of child immunity, resulting in decreased child antibody levels against vaccines. (C) 2016 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)354-363
    Number of pages10
    JournalEnvironmental Pollution
    Volume220
    DOIs
    Publication statusPublished - Jan-2017

    Keywords

    • Metals
    • Metalloids
    • Electronic waste
    • Vaccine antibodies
    • Preschool children
    • BLOOD LEAD LEVELS
    • LOW-COST JEWELRY
    • ELECTRONIC-WASTE
    • RECYCLING AREA
    • HEAVY-METALS
    • IMMUNE-RESPONSE
    • IN-VITRO
    • HEALTH CONSEQUENCES
    • CHINA
    • CADMIUM

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