Deep brain stimulation in the nucleus accumbens for binge eating disorder: A study in rats

D L Marinus Oterdoom; Renske Lok; André P van Beek; Wilfred F A den Dunnen; Marloes Emous; J Marc C van Dijk; Gertjan van Dijk

doi:10.1007/s11695-020-04697-9

Deep brain stimulation in the nucleus accumbens for binge eating disorder: A study in rats

D L Marinus Oterdoom, Renske Lok, André P van Beek, Wilfred F A den Dunnen, Marloes Emous, J Marc C van Dijk, Gertjan van Dijk^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twenty-one male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol. Binge eating was significantly reduced with DBS during (NAC core) or before (NAC lateral shell) the binge. These outcomes provide a base to further explore the potential of DBS in the treatment of BED.

Original language	English
Pages (from-to)	4145-4148
Number of pages	4
Journal	Obesity Surgery
Volume	30
Issue number	10
Early online date	2020
DOIs	https://doi.org/10.1007/s11695-020-04697-9
Publication status	Published - Oct-2020

Keywords

Deep brain stimulation
Nucleus accumbens
Binge eating disorder
Animal study
LIKING

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Deep Brain Stimulation in the Nucleus Accumbens for Binge EatingFinal publisher's version, 390 KBLicence: CC BY

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title = "Deep brain stimulation in the nucleus accumbens for binge eating disorder: A study in rats",

abstract = "Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twenty-one male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol. Binge eating was significantly reduced with DBS during (NAC core) or before (NAC lateral shell) the binge. These outcomes provide a base to further explore the potential of DBS in the treatment of BED.",

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T2 - A study in rats

AU - Oterdoom, D L Marinus

AU - Lok, Renske

AU - van Beek, André P

AU - den Dunnen, Wilfred F A

AU - Emous, Marloes

AU - van Dijk, J Marc C

AU - van Dijk, Gertjan

PY - 2020/10

Y1 - 2020/10

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AB - Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twenty-one male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol. Binge eating was significantly reduced with DBS during (NAC core) or before (NAC lateral shell) the binge. These outcomes provide a base to further explore the potential of DBS in the treatment of BED.

KW - Deep brain stimulation

KW - Nucleus accumbens

KW - Binge eating disorder

KW - Animal study

KW - LIKING

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DO - 10.1007/s11695-020-04697-9

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ER -

Deep brain stimulation in the nucleus accumbens for binge eating disorder: A study in rats

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