Deep brain stimulation in the nucleus accumbens for binge eating disorder: A study in rats

D L Marinus Oterdoom, Renske Lok, André P van Beek, Wilfred F A den Dunnen, Marloes Emous, J Marc C van Dijk, Gertjan van Dijk*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Binge eating disorder (BED), with its compulsive and addictive components, may often underlie weight regain after gastrointestinal bariatric surgeries. BED is therefore considered an exclusion criterion for these surgeries. Anecdotal reports suggest that deep brain stimulation (DBS) is an effective treatment for addictive disorders with, similar to BED, pathological changes in cerebral reward circuitry. We therefore assessed effect of DBS of the nucleus accumbens (NAC) in a rat model of BED. Twenty-one male obesity prone Wistar rats with DBS electrodes placed in NAC subregions were subjected to a binge eating protocol. Binge eating was significantly reduced with DBS during (NAC core) or before (NAC lateral shell) the binge. These outcomes provide a base to further explore the potential of DBS in the treatment of BED.

Original languageEnglish
Pages (from-to)4145-4148
Number of pages4
JournalObesity Surgery
Volume30
Issue number10
DOIs
Publication statusE-pub ahead of print - 2020

Keywords

  • Deep brain stimulation
  • Nucleus accumbens
  • Binge eating disorder
  • Animal study
  • LIKING

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