Default Mode Network Connectivity and Social Dysfunction in Major Depressive Disorder

Ilja M. J. Saris*, Brenda W. J. H. Penninx, Richard Dinga, Marie-Jose van Tol, Dick J. Veltman, Nic J. A. van der Wee, Moji Aghajani

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
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Abstract

Though social functioning is often hampered in Major Depressive Disorder (MDD), we lack a complete and integrated understanding of the underlying neurobiology. Connectional disturbances in the brain's Default Mode Network (DMN) might be an associated factor, as they could relate to suboptimal social processing. DMN connectional integrity, however, has not been explicitly studied in relation to social dysfunctioning in MDD patients. Applying Independent Component Analysis and Dual Regression on resting-state fMRI data, we explored DMN intrinsic functional connectivity in relation to social dysfunctioning (i.e. composite of loneliness, social disability, small social network) among 74 MDD patients (66.2% female, Mean age=36.9, SD=11.9). Categorical analyses examined whether DMN connectivity differs between high and low social dysfunctioning MDD groups, dimensional analyses studied linear associations between social dysfunction and DMN connectivity across MDD patients. Threshold-free cluster enhancement (TFCE) with family-wise error (FWE) correction was used for statistical thresholding and multiple comparisons correction (P

Original languageEnglish
Article number194
Number of pages11
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - 13-Jan-2020

Keywords

  • STATE FUNCTIONAL CONNECTIVITY
  • DIMENSIONAL APPROACH
  • ACTIVATION
  • HEALTH
  • 1ST-EPISODE
  • SCHIZOPHRENIA
  • DISABILITY
  • COGNITION
  • SUPPORT
  • CORTEX

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