Defining anxious depression in later life: A scaring heterogeneity in results

D.C. van der Veen; Hannie C Comijs; Willeke H van Zelst; Robert A Schoevers; Richard C Oude Voshaar

doi:10.1016/j.jagp.2014.02.012

Defining anxious depression in later life: A scaring heterogeneity in results

D.C. van der Veen, Hannie C Comijs, Willeke H van Zelst, Robert A Schoevers, Richard C Oude Voshaar

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

BACKGROUND: Anxiety in depression is challenging as it results in more functional impairment and a worse prognosis. No consensus exists on the definition of anxious depression.

METHODS: In 359 older patients with major depressive disorder, we examined the agreement between anxious depression based on different combinations of comorbid anxiety disorders and anxious depression based on high level of anxiety symptoms measured by self-report questionnaires.

RESULTS: Agreement between the definitions of anxious depression was poor, as indicated by κ statistics ranging between 0.06 and 0.23.

CONCLUSION: Accepted criteria for anxious depression classify completely different patients as being anxious depressed. This may explain inconsistent results of previous studies on anxious depression. Moreover, progress in this research field is hampered, as studies using different definitions cannot be pooled in meta-analyses.

Original language	English
Pages (from-to)	1375-1378
Number of pages	4
Journal	American Journal of Geriatric Psychiatry
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.jagp.2014.02.012
Publication status	Published - Nov-2014

Keywords

Mixed anxiety depression
anxious depression
late-life depression
depression
comorbidity
GENERALIZED ANXIETY DISORDER
DIAGNOSTIC INTERVIEW
COOCCURRENCE
RELIABILITY
INVENTORY
PATTERNS

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title = "Defining anxious depression in later life: A scaring heterogeneity in results",

abstract = "BACKGROUND: Anxiety in depression is challenging as it results in more functional impairment and a worse prognosis. No consensus exists on the definition of anxious depression.METHODS: In 359 older patients with major depressive disorder, we examined the agreement between anxious depression based on different combinations of comorbid anxiety disorders and anxious depression based on high level of anxiety symptoms measured by self-report questionnaires.RESULTS: Agreement between the definitions of anxious depression was poor, as indicated by κ statistics ranging between 0.06 and 0.23.CONCLUSION: Accepted criteria for anxious depression classify completely different patients as being anxious depressed. This may explain inconsistent results of previous studies on anxious depression. Moreover, progress in this research field is hampered, as studies using different definitions cannot be pooled in meta-analyses.",

keywords = "Mixed anxiety depression, anxious depression, late-life depression, depression, comorbidity, GENERALIZED ANXIETY DISORDER, DIAGNOSTIC INTERVIEW, COOCCURRENCE, RELIABILITY, INVENTORY, PATTERNS",

author = "{van der Veen}, D.C. and Comijs, {Hannie C} and {van Zelst}, {Willeke H} and Schoevers, {Robert A} and {Oude Voshaar}, {Richard C}",

year = "2014",

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doi = "10.1016/j.jagp.2014.02.012",

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T2 - A scaring heterogeneity in results

AU - van der Veen, D.C.

AU - Comijs, Hannie C

AU - van Zelst, Willeke H

AU - Schoevers, Robert A

AU - Oude Voshaar, Richard C

PY - 2014/11

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N2 - BACKGROUND: Anxiety in depression is challenging as it results in more functional impairment and a worse prognosis. No consensus exists on the definition of anxious depression.METHODS: In 359 older patients with major depressive disorder, we examined the agreement between anxious depression based on different combinations of comorbid anxiety disorders and anxious depression based on high level of anxiety symptoms measured by self-report questionnaires.RESULTS: Agreement between the definitions of anxious depression was poor, as indicated by κ statistics ranging between 0.06 and 0.23.CONCLUSION: Accepted criteria for anxious depression classify completely different patients as being anxious depressed. This may explain inconsistent results of previous studies on anxious depression. Moreover, progress in this research field is hampered, as studies using different definitions cannot be pooled in meta-analyses.

AB - BACKGROUND: Anxiety in depression is challenging as it results in more functional impairment and a worse prognosis. No consensus exists on the definition of anxious depression.METHODS: In 359 older patients with major depressive disorder, we examined the agreement between anxious depression based on different combinations of comorbid anxiety disorders and anxious depression based on high level of anxiety symptoms measured by self-report questionnaires.RESULTS: Agreement between the definitions of anxious depression was poor, as indicated by κ statistics ranging between 0.06 and 0.23.CONCLUSION: Accepted criteria for anxious depression classify completely different patients as being anxious depressed. This may explain inconsistent results of previous studies on anxious depression. Moreover, progress in this research field is hampered, as studies using different definitions cannot be pooled in meta-analyses.

KW - Mixed anxiety depression

KW - anxious depression

KW - late-life depression

KW - depression

KW - comorbidity

KW - GENERALIZED ANXIETY DISORDER

KW - DIAGNOSTIC INTERVIEW

KW - COOCCURRENCE

KW - RELIABILITY

KW - INVENTORY

KW - PATTERNS

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JO - American Journal of Geriatric Psychiatry

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ER -

Defining anxious depression in later life: A scaring heterogeneity in results

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Keywords

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