delta 1-Tetrahydrocannabinol-induced circling behavior in rats: a possible measure of psychotomimetic activity?

I Nir, H D Veldhuis, J M van Ree

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Relatively high dosages of delta 1-tetrahydrocannabinol (delta 1-THC) markedly suppressed almost all normally occurring behavioral elements in rats as observed in both a small and a large open field. This effect persisted following repeated treatment and testing for 3 consecutive days. The psychotropically inert but related compound cannabidiol (CBD) did not suppress behavior, but in contrast had a mild activating effect. Both compounds decreased defecation during the test procedure. In addition, delta 1-THC, but not CBD, induced a bizarre circling and turning response, that was evident over all 3 test days and occurred even when the rats were deeply sedated. It is suggested that an analysis of this phenomenon may be useful in measuring the psychotomimetic action of delta 1-THC and similar compounds in rats.

    Original languageEnglish
    Pages (from-to)556-60
    Number of pages5
    JournalPsychopharmacology
    Volume84
    Issue number4
    Publication statusPublished - 1984

    Keywords

    • Animals
    • Cannabidiol
    • Defecation
    • Dose-Response Relationship, Drug
    • Dronabinol
    • Hallucinogens
    • Humans
    • Male
    • Motor Activity
    • Phencyclidine
    • Rats
    • Rats, Inbred Strains
    • Stereotyped Behavior

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