Dengue tropism for macrophages and dendritic cells: the host cell effect

Jacky Flipse, Silvia Torres Pedraza, Mayra Diosa-Toro, Heidi van der Ende-Metselaar, Jose Herrera-Rodriguez, Silvio Urcuqui-Inchima, Anke Huckriede, Izabela A Rodenhuis-Zybert, Jolanda M Smit

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC derived virus. Taken together, our results highlight the importance of macrophages in dengue infection.

Original languageEnglish
Pages (from-to)1531-1536
Number of pages6
JournalThe Journal of general virology
Volume97
DOIs
Publication statusPublished - Jul-2016

Keywords

  • ANTIBODY-DEPENDENT ENHANCEMENT
  • VIRUS-INFECTION
  • TARGET-CELLS
  • PARTICLES
  • DISEASE
  • TISSUES
  • CLEC5A
  • ENTRY

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