Dermatitis herpetiformis

Barbara Horváth; Marcel F. Jonkman

doi:10.1007/978-3-030-91557-5_20

Dermatitis herpetiformis

Barbara Horváth^*, Marcel F. Jonkman

^*Corresponding author for this work

Translational Immunology Groningen (TRIGR)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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Abstract

Dermatitis herpetiformis (DH) is the specific skin manifestation of coeliac disease (CD) caused by the digestion of gluten in HLA-DQ2 or HLA-DQ8 individuals. DH is characterized by intensely pruritic polymorphic papulovesicular eruption on the extensor surfaces of the body. Both diseases are characterized by circulating IgA autoantibodies against tissue transglutaminase (tTG), which bind to the smooth muscle layer of the monkey esophagus causing the so-called EMA positivity. Additionally DH patient have another autoantibody population targeting the epidermal transglutaminase (eTG), the autoantigen of DH, which protein is highly homologous to tTG.

Original language	English
Title of host publication	Autoimmune Bullous Diseases
Subtitle of host publication	Text and Review
Publisher	Springer International Publishing AG
Chapter	20
Pages	157-164
Number of pages	8
ISBN (Electronic)	9783030915575
ISBN (Print)	9783030915568
DOIs	https://doi.org/10.1007/978-3-030-91557-5_20
Publication status	Published - 19-Jan-2022

Keywords

Celiac disease
Dapsone
Dermatitis herpetiformis (DH)
Epidermal transglutaminase (eTG)
Gluten sensitive disease (GSD)
Immunoglobuline A (IgA)
Tissue transglutaminase (tTG)

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10.1007/978-3-030-91557-5_20

Dermatitis HerpetiformisFinal publisher's version, 706 KBLicence: Taverne

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title = "Dermatitis herpetiformis",

abstract = "Dermatitis herpetiformis (DH) is the specific skin manifestation of coeliac disease (CD) caused by the digestion of gluten in HLA-DQ2 or HLA-DQ8 individuals. DH is characterized by intensely pruritic polymorphic papulovesicular eruption on the extensor surfaces of the body. Both diseases are characterized by circulating IgA autoantibodies against tissue transglutaminase (tTG), which bind to the smooth muscle layer of the monkey esophagus causing the so-called EMA positivity. Additionally DH patient have another autoantibody population targeting the epidermal transglutaminase (eTG), the autoantigen of DH, which protein is highly homologous to tTG.",

keywords = "Celiac disease, Dapsone, Dermatitis herpetiformis (DH), Epidermal transglutaminase (eTG), Gluten sensitive disease (GSD), Immunoglobuline A (IgA), Tissue transglutaminase (tTG)",

author = "Barbara Horv{\'a}th and Jonkman, {Marcel F.}",

year = "2022",

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day = "19",

doi = "10.1007/978-3-030-91557-5_20",

language = "English",

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pages = "157--164",

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T1 - Dermatitis herpetiformis

AU - Horváth, Barbara

AU - Jonkman, Marcel F.

PY - 2022/1/19

Y1 - 2022/1/19

N2 - Dermatitis herpetiformis (DH) is the specific skin manifestation of coeliac disease (CD) caused by the digestion of gluten in HLA-DQ2 or HLA-DQ8 individuals. DH is characterized by intensely pruritic polymorphic papulovesicular eruption on the extensor surfaces of the body. Both diseases are characterized by circulating IgA autoantibodies against tissue transglutaminase (tTG), which bind to the smooth muscle layer of the monkey esophagus causing the so-called EMA positivity. Additionally DH patient have another autoantibody population targeting the epidermal transglutaminase (eTG), the autoantigen of DH, which protein is highly homologous to tTG.

AB - Dermatitis herpetiformis (DH) is the specific skin manifestation of coeliac disease (CD) caused by the digestion of gluten in HLA-DQ2 or HLA-DQ8 individuals. DH is characterized by intensely pruritic polymorphic papulovesicular eruption on the extensor surfaces of the body. Both diseases are characterized by circulating IgA autoantibodies against tissue transglutaminase (tTG), which bind to the smooth muscle layer of the monkey esophagus causing the so-called EMA positivity. Additionally DH patient have another autoantibody population targeting the epidermal transglutaminase (eTG), the autoantigen of DH, which protein is highly homologous to tTG.

KW - Celiac disease

KW - Dapsone

KW - Dermatitis herpetiformis (DH)

KW - Epidermal transglutaminase (eTG)

KW - Gluten sensitive disease (GSD)

KW - Immunoglobuline A (IgA)

KW - Tissue transglutaminase (tTG)

U2 - 10.1007/978-3-030-91557-5_20

DO - 10.1007/978-3-030-91557-5_20

M3 - Chapter

AN - SCOPUS:85156184346

SN - 9783030915568

SP - 157

EP - 164

BT - Autoimmune Bullous Diseases

PB - Springer International Publishing AG

ER -

Dermatitis herpetiformis

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