Abstract
A terphenyl α-helix mimetic scaffold recognized to be capable of disrupting protein-protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthesis, initial cell based biological data, and preliminary in vitro screening for the disruption of the Bcl-w/Bak protein-protein interaction by representatives of the MCR derived scaffold are presented.
Original language | English |
---|---|
Pages (from-to) | 1740-1743 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 16 |
Issue number | 6 |
DOIs | |
Publication status | Published - 15-Mar-2006 |
Keywords
- Apoptosis
- Bcl family
- Cancer
- Isocyanide
- Multicomponent reaction
- Protein interaction antagonist
- imidazole
- terphenyl derivative
- alpha helix
- apoptosis
- article
- cell proliferation
- enzyme inhibition
- protein protein interaction
- protein structure
- protein synthesis