Desmin-related myopathy

K. Y. van Spaendonck-Zwarts*, L. van Hessem, J. D. H. Jongbloed, H. E. K. de Walle, Y. Capetanaki, A. J. van der Kooi, I. M. van Langen, M. P. van den Berg, J. P. van Tintelen

*Corresponding author for this work

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129 Citations (Scopus)

Abstract

Desmin-related myopathy (DRM) is an autosomally inherited skeletal and cardiac myopathy, mainly caused by dominant mutations in the desmin gene (DES). We provide (i) a literature review on DRM, including clinical manifestations, inheritance, molecular genetics, myopathology and management and (ii) a meta-analysis of reported DES mutation carriers, focusing on their clinical characteristics and potential genotype-phenotype correlations. Meta-analysis: DES mutation carriers (n = 159) with 40 different mutations were included. Neurological signs were present in 74% and cardiological signs in 74% of carriers (both neurological and cardiological signs in 49%, isolated neurological signs in 22%, and isolated cardiological signs in 22%). More than 70% of carriers exhibited myopathy or muscular weakness, with normal creatine kinase levels present in one third of them. Up to 50% of carriers had cardiomyopathy and around 60% had cardiac conduction disease or arrhythmias, with atrioventricular block as an important hallmark. Symptoms generally started during the 30s; a quarter of carriers died at a mean age of 49 years. Sudden cardiac death occurred in two patients with a pacemaker, suggesting a ventricular tachyarrhythmia as cause of death. The majority of DES mutations were missense mutations, mostly located in the 2B domain. Mutations in the 2B domain were predominant in patients with an isolated neurological phenotype, whereas head and tail domain mutations were predominant in patients with an isolated cardiological phenotype.

Original languageEnglish
Pages (from-to)354-366
Number of pages13
JournalClinical Genetics
Volume80
Issue number4
DOIs
Publication statusPublished - Oct-2011

Keywords

  • cardiomyopathy
  • cardiac-phenotype
  • desmin
  • mutation
  • myopathy
  • ALPHA-B-CRYSTALLIN
  • DOMINANT DISTAL MYOPATHY
  • SKELETAL MYOPATHY
  • INTERMEDIATE-FILAMENTS
  • DILATED CARDIOMYOPATHY
  • RESTRICTIVE CARDIOMYOPATHY
  • CLINICAL CHARACTERISTICS
  • MYOFIBRILLAR MYOPATHIES
  • CARDIOSKELETAL MYOPATHY
  • MISSENSE MUTATION

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