Detecting free radicals post viral infections

V. G. Damle; K. Wu; D. J. Arouri; R. Schirhagl

doi:10.1016/j.freeradbiomed.2022.08.013

Detecting free radicals post viral infections

V. G. Damle
, K. Wu
, D. J. Arouri
, R. Schirhagl^*

^*Corresponding author for this work

Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

303 Downloads (Pure)

Abstract

Free radical generation plays a key role in viral infections. While free radicals have an antimicrobial effect on bacteria or fungi, their interplay with viruses is complicated and varies greatly for different types of viruses as well as different radical species. In some cases, radical generation contributes to the defense against the viruses and thus reduces the viral load. In other cases, radical generation induces mutations or damages the host tissue and can increase the viral load. This has led to antioxidants being used to treat viral infections. Here we discuss the roles that radicals play in virus pathology. Furthermore, we critically review methods that facilitate the detection of free radicals in vivo or in vitro in viral infections.

Original language	English
Pages (from-to)	8-23
Number of pages	16
Journal	Free Radical Biology and Medicine
Volume	191
DOIs	https://doi.org/10.1016/j.freeradbiomed.2022.08.013
Publication status	Published - Oct-2022

Keywords

Detection techniques
Free radicals
Sensing
Viral infections

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10.1016/j.freeradbiomed.2022.08.013Licence: CC BY

Detecting free radicals post viral infectionsFinal publisher's version, 6.52 MBLicence: CC BY

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@article{cfc6c5808a784b9f85163a5121a39285,

title = "Detecting free radicals post viral infections",

abstract = "Free radical generation plays a key role in viral infections. While free radicals have an antimicrobial effect on bacteria or fungi, their interplay with viruses is complicated and varies greatly for different types of viruses as well as different radical species. In some cases, radical generation contributes to the defense against the viruses and thus reduces the viral load. In other cases, radical generation induces mutations or damages the host tissue and can increase the viral load. This has led to antioxidants being used to treat viral infections. Here we discuss the roles that radicals play in virus pathology. Furthermore, we critically review methods that facilitate the detection of free radicals in vivo or in vitro in viral infections.",

keywords = "Detection techniques, Free radicals, Sensing, Viral infections",

author = "Damle, \{V. G.\} and K. Wu and Arouri, \{D. J.\} and R. Schirhagl",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = oct,

doi = "10.1016/j.freeradbiomed.2022.08.013",

language = "English",

volume = "191",

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TY - JOUR

T1 - Detecting free radicals post viral infections

AU - Damle, V. G.

AU - Wu, K.

AU - Arouri, D. J.

AU - Schirhagl, R.

PY - 2022/10

Y1 - 2022/10

N2 - Free radical generation plays a key role in viral infections. While free radicals have an antimicrobial effect on bacteria or fungi, their interplay with viruses is complicated and varies greatly for different types of viruses as well as different radical species. In some cases, radical generation contributes to the defense against the viruses and thus reduces the viral load. In other cases, radical generation induces mutations or damages the host tissue and can increase the viral load. This has led to antioxidants being used to treat viral infections. Here we discuss the roles that radicals play in virus pathology. Furthermore, we critically review methods that facilitate the detection of free radicals in vivo or in vitro in viral infections.

AB - Free radical generation plays a key role in viral infections. While free radicals have an antimicrobial effect on bacteria or fungi, their interplay with viruses is complicated and varies greatly for different types of viruses as well as different radical species. In some cases, radical generation contributes to the defense against the viruses and thus reduces the viral load. In other cases, radical generation induces mutations or damages the host tissue and can increase the viral load. This has led to antioxidants being used to treat viral infections. Here we discuss the roles that radicals play in virus pathology. Furthermore, we critically review methods that facilitate the detection of free radicals in vivo or in vitro in viral infections.

KW - Detection techniques

KW - Free radicals

KW - Sensing

KW - Viral infections

U2 - 10.1016/j.freeradbiomed.2022.08.013

DO - 10.1016/j.freeradbiomed.2022.08.013

M3 - Review article

C2 - 36002131

AN - SCOPUS:85137111844

SN - 0891-5849

VL - 191

SP - 8

EP - 23

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Detecting free radicals post viral infections

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Keywords

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