DETERMINATION OF A MAXIMUM NUMBER OF ARTIFICIAL INSEMINATIONS BY DONOR CHILDREN PER SPERM DONOR

A DEBOER, JC Oosterwijk, CAE RIGTERSARIS

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

20 Citations (Scopus)

Abstract

Objective: To determine a safe maximum number of artificial insemination (donor insemination [DI]) children per anonymous sperm donor.

Design: Multiparameter calculation model of contribution of DI to inbreeding.

Setting: Data of the collaborative DI centers and demographic population data of The Netherlands.

Interventions: Calculations of the contribution of DI to inbreeding were made, taking into account all possible unintentional consanguineous matings and consanguineous inseminations with a coefficient of inbreeding (F) of greater than or equal to 1/16 for the offspring.

Main Outcome Measure: Coefficient of inbreeding (F).

Results: The contribution of DI to inbreeding was estimated to be 46.6 X 10(-6) + k (1.66 X 10(-6)) (k = number of DI children per donor). When only half-sibling matings were considered, the k(max) was 32. When all possible consanguineous matings and inseminations were taken into account, k(max) decreased with 28% to 25 children.

Conclusion: Calculations of a maximum number of DI children per sperm donor, based on possible enhancement of inbreeding and given the Dutch population and DI setting, show that 25 children per DI donor is a safe threshold for clinical practice.

Original languageEnglish
Pages (from-to)419-421
Number of pages3
JournalFertility and sterility
Volume63
Issue number2
Publication statusPublished - Feb-1995

Keywords

  • ARTIFICIAL INSEMINATION WITH DONOR SPERM
  • INBREEDING
  • CONSANGUINITY

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