Determination of the enantiomeric purity of (−−) 2‐(N‐propyl‐n‐2‐thienylethylamino)‐5‐hydroxytetralin (n‐0923) by chiral stationary phase HPLC

Dirk T. Witte*, Jan Piet Franke, Pieter J. Swart, Rokus A. de Zeeuw

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    12 Citations (Scopus)

    Abstract

    The determination of the enantiomeric impurity, i.e, the percentage of (+) N-0437 (= N-0924) in several batches of (-) N-0437 (= N-0923) by chiral HPLC is described. Enantiomeric impurities were calculated based on the peak areas of the two baseline separated enantiomers in the chromatogram. The enantiomeric impurities found in different batches ranged from 0.02% to 0.11%. Calibration curves of the two isomers of N-0437 (Fig. 1,) were made twice to study the reproducibility and linearity of the method. The absorbance ratio, N-0923/N-0924, was found to be 1.02 with a relative standard deviation (RSD) of 9% over the whole concentration range used for the calibration curves.

    Original languageEnglish
    Pages (from-to)62-64
    Number of pages3
    JournalChirality
    Volume4
    Issue number1
    DOIs
    Publication statusPublished - 1992

    Keywords

    • DOPAMINE AGONIST
    • DIRECT CHIRAL SEPARATION
    • CELLULOSE CARBAMATE STATIONARY PHASE
    • N-0437
    • SEPARATION

    Cite this