Determine effect of weight loss on serum level of inflammatory cytokines IL 1 IL 6 CRP and TNF α in obese patients with fatty liver disease

Introduction: Obesity which is connected to a wide range of functional and hormonal disorders, results is a mild and chronic inflammatory state leading to long term adverse effects. The aim of this study is to evaluate effect of low calorie diet and weight loss on serum level of inflammatory markers in patients with fatty liver disease in Iranian population. Methods: In a clinical trial, 40 patients with fatty liver disease in Gastro-hepatology clinic of Tabriz Imam Reza hospital, who fulfilled the inclusion criteria, were introduced to receive a low calorie diet in nutrition clinic. Serum level of proinflammatory factors (IL-1, IL-6, TNF-α and Hs-CRP) were measured and compared before and after a 8 week trial of diet. Results: The mean value of weight and body mass index of participants decreased significantly (a mean decrease of 6.47 ± 3.40 percent in weight) after 8 weeks. Weight loss in men was significantly more than women. The mean level of IL-1, IL-6, TNF-α and Hs-CRP was significantly decreased after weight loss in both men and women. There was no correlation between amount of weight loss (or decrease in BMI or percentage of weight loss) with decrease of IL-1, IL-6, TNF-α or Hs- CRP. Decrease of TNF-α was more in younger patients. Conclusion: Weight loss with low calorie diet can decrease the level of IL-1, IL-6, TNF-α and Hs-CRP of patients with fatty liver during 8 weeks independent from gender and degree of weight loss.